Nature Search

Distal protein-protein interactions contribute to nirmatrelvir resistance

Non-active site mutations such as L50F are crucial for restoring the viral fitness of SARS-CoV-2 main protease. Here, the authors use full-length Mpro protein as substrate and demonstrate that L50F can promote the formation of enzyme-substrate complex and thus contribute to nirmatrelvir resistance.

Eric M. Lewandowski
Xiujun Zhang
Yu Chen
ResearchOpen Access01 Feb 2025
Nature Communications

Volume: 16, P: 1-8
Time-domain signatures of distinct correlated insulators in a moiré superlattice

The nature of correlated insulator states commonly observed in moiré superlattices are still under investigation. Here, the authors use pump-probe spectroscopy to study the dynamics of correlated insulator states in a WSe₂/WS₂ moiré heterostructure at two different fillings, elucidating distinct time-domain signatures associated with these states.

Eric A. Arsenault
Yiliu Li
X.-Y. Zhu
ResearchOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1-8
Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation

Yuan Zhang
Paul V. Taufalele
E. Dale Abel
Amendments and Corrections18 Nov 2020
Nature Metabolism

Volume: 2, P: 1498
A unique class of Zn²⁺-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

Antibiotics of the β-lactam class inhibit bacterial cell wall synthesis by targeting penicillin-binding proteins (PBPs). Here, Sacco et al. study the four PBPs present in the pathogen C. difficile, revealing unique structural features and shedding light on the mechanisms underlying β-lactam resistance in this organism.

Michael D. Sacco
Shaohui Wang
Yu Chen
ResearchOpen Access28 Jul 2022
Nature Communications

Volume: 13, P: 1-13
Mitochondrial pyruvate carriers are required for myocardial stress adaptation

Metabolic substrate partitioning underlies myocardial homeostatic capacity and adaptation to stress. Zhang et al. show that decreasing mitochondrial pyruvate carrier expression redirects glycolytic intermediates and leads to heart failure, which is prevented or reversed with a high-fat or ketogenic diet.

Yuan Zhang
Paul V. Taufalele
E. Dale Abel
Research26 Oct 2020
Nature Metabolism

Volume: 2, P: 1248-1264
TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation

Transcriptional regulation of the interferon-β gene (Ifnb1) in macrophages is a critical immune event. Here, Ferri et al. show that, at late phases of macrophages activation, TRIM33 bound to a distal repressor element suppresses Ifnb1transcription by preventing recruitment of CBP/p300.

Federica Ferri
Aude Parcelier
Paul-Henri Romeo
ResearchOpen Access23 Nov 2015
Nature Communications

Volume: 6, P: 1-12
The in vivo genetic program of murine primordial lung epithelial progenitors

The identity of the earliest murine in vivo lung epithelial progenitors (marked by NKX2-1 expression) is unclear. Here, the authors use single-cell RNA sequencing to define the genetic program of these lung primordial progenitors, which will improve in vitro lung specification of pluripotent stem cells.

Laertis Ikonomou
Michael J. Herriges
Darrell N. Kotton
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program

Jean Addington
Lu Liu
Alison R. Yung
ResearchOpen Access03 Apr 2025
Schizophrenia

Volume: 11, P: 1-10
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample

Kelly Allott
Walid Yassin
William S. Stone
ResearchOpen Access24 Mar 2025
Schizophrenia

Volume: 11, P: 1-12
Expression of estrogen receptor β isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

Chunyan Zhao
Eric W-F Lam
Karin Dahlman-Wright
Research23 Oct 2003
Oncogene

Volume: 22, P: 7600-7606
The apple REFPOP—a reference population for genomics-assisted breeding in apple

Michaela Jung
Morgane Roth
Hélène Muranty
ResearchOpen Access01 Nov 2020
Horticulture Research

Volume: 7, P: 1-16
Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Daniel R. Dempsey
Derek A. Nichols
David J. Merkler
ResearchOpen Access18 Oct 2017
Scientific Reports

Volume: 7, P: 1-15
Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm

Christina Y L Aye
Adam J Lewandowski
Paul Leeson
ResearchOpen Access24 May 2017
Pediatric Research

Volume: 82, P: 36-46
Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations

Andrew S. Michalski
Shreyasee Amin
Jean D. Sibonga
ResearchOpen Access14 Mar 2019
npj Microgravity

Volume: 5, P: 1-10

Search

Distal protein-protein interactions contribute to nirmatrelvir resistance

Time-domain signatures of distinct correlated insulators in a moiré superlattice

Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation

A unique class of Zn²⁺-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

Mitochondrial pyruvate carriers are required for myocardial stress adaptation

TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation

The in vivo genetic program of murine primordial lung epithelial progenitors

Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program

Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample

Expression of estrogen receptor β isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

The apple REFPOP—a reference population for genomics-assisted breeding in apple

Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine

Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm

Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations

Search

Quick links

Search

Filter By:

Search

Quick links