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Stolier et al. find that people apply their learned conceptual associations between personality traits across social perception, from which emerges the common, yet dynamic, structure observed across social cognition (for example, competence and warmth).

Understanding why people hesitated to seek COVID-19 vaccines after they became available can inform public health policies. Here, the authors use search engine data to infer vaccination rates and intentions across the United States, then develop a taxonomy of vaccine concerns and identify the most prevalent apprehensions.

This study finds that decision markets can be a useful tool for selecting studies for replication. For a sample of 26 online experiments published in PNAS selected by a decision market, the authors find replication rates ranging between 54% and 62%.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Little is known about how temperature anomalies affect people’s views about climate change. Research now shows that available information about today’s temperature, even though less relevant than evidence of global patterns, is used to formulate opinions. With experience of abnormal temperatures, people overestimate the frequency of similar past events and belief in global warming increases.

The authors show that in a creative setting people make choices partially based on how empowering their choices are.

Itkin et al. identify a role for Fli-1 in hematopoietic stem cell activation during regenerative hematopoiesis. They show that Fli-1 coordinates hematopoietic stem cells to stimulate niche-derived Notch1 feedback signals for demand-needed hematopoietic cell output.

Analyses of 475 ancient horse genomes show modern horses emerged around 2200 bce, coinciding with sudden expansion across Eurasia, refuting the narrative of large horse herds accompanying earlier migrations of steppe peoples across Europe.

Studying behaviour in a decision-making task with multiple features and changing reward functions, Tomov et al. find that a strategy that combines successor features with generalized policy iteration predicts behaviour best.

This Review discusses the advantages and limitations of self-supervised methods and models for use in medicine and healthcare, and the challenges in collecting unbiased data for their training.

Obesity and inflammation have been associated to cancer progression. Here, the authors show that high fat and cholesterol diet, in a non-obese context, promotes tumourigenesis through increasing inflammatory monocytes and myeloid-derived pro-angiogenic factors.

Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops.

Beliefs that justify the economic system buffer against the aversive emotional impact of inequality. Here the authors show that system-justifying economic ideology predicts dampened negativity, measured using self-reported and physiological responses, to manifestations of poverty and wealth.

Using the 4-D model of advantaged identity management and latent profile analysis this study identifies five groups of white Americans, links these groups to distinct values, and shows they predict responses to racial equality and social change.

To study cognition, researchers have traditionally used laboratory-based experiments, but games offer a valuable alternative: they are intuitive and enjoyable. In this Perspective, Schulz et al. discuss the advantages and drawbacks of games and give recommendations for researchers.

Camerer et al. carried out replications of 21 Science and Nature social science experiments, successfully replicating 13 out of 21 (62%). Effect sizes of replications were about half of the size of the originals.

A novel theoretical framework reveals how topography surrounding rivers causes dramatic changes in their courses, with implications for natural hazard prediction, particularly in the Global South.

In the randomized, double-blind, phase 3 GLOW trial, capecitabine and oxaliplatin combined with zolbetuximab, a monoclonal antibody that targets CLDN18.2, significantly improved progression-free survival and overall survival in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Traumatic brain injury can result in long-lasting symptoms and is associated with progressive neurodegenerative and neuroinflammatory pathology, but biomarkers to diagnose and monitor these chronic effects are lacking. Here, Thelin and co-workers summarize the available evidence for fluid biomarker use in chronic traumatic brain injury.

Dynamic cross-species single cell transcriptomic analyses reveal conserved and disparate cardiac and extracardiac inflammatory responses upon heart injury between models with fibrotic and regenerative outcomes.

When searching for rewards in complex, unfamiliar environments, it is often impossible to explore all options. Wu et al. show how a combination of generalization and optimistic sampling guides efficient human exploration in complex environments.

Patel et al. perform a comprehensive analysis of factors associated with HIV positivity across 29 sub-Saharan African countries from 2003 to 2017. They identify over 300 factors associated with HIV positivity in each sex, some of them under-recognized but consistent across countries and sex.

This study uses data from patients with damage to specific parts of the frontal cortex to provide causal evidence for the role of the dorsolateral prefrontal cortex in enabling honest behavior. Damage to this area was associated with decisions that prioritized the decision-maker's own self-interest, at the cost of honesty.

Structural and functional analyses of yeast metacaspase reveal unique Ca²⁺ and Mg²⁺ binding sites and provide insights into Ca²⁺-dependent maturation of metacaspases along with the inhibitory effects of Mg²⁺ and Zn²⁺.