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Showing 1–2 of 2 results
Advanced filters: Author: Erignacio Fermin Perez Clear advanced filters

  • Most proteases require a catalytic triad for enzymatic function. N-terminal nucleophile enzymes such as the proteasome are unique in possessing two nucleophiles. Here the authors provide evidence that such enzymes utilize a catalytic pentad mechanism that allows for regulation of both nucleophiles.

    • Darlene Fung
    • Aida Razi
    • John Hanna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • To prevent promiscuous protein degradation, proteasomes are initially assembled as inactive complexes. Their activation is autocatalytic and coupled to assembly. Here the authors uncover key aspects of the autocatalytic activation mechanism.

    • Benjamin Velez
    • Richard M. Walsh Jr.
    • John Hanna
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1167-1175