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Showing 1–3 of 3 results
Advanced filters: Author: Eriko Naganuma Clear advanced filters

  • Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability.

    • Takafumi Suzuki
    • Shiori Seki
    • Masayuki Yamamoto
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Using Nrf2 knockout mice, Suzuki, Uruno, Yumoto et al. show that space travel activates Nrf2 signaling, which contributes to the weight gain of mice by regulating fat metabolism of white adipose tissues. This study provides insights into potential interventions to mitigate stresses that accompany space travels.

    • Takafumi Suzuki
    • Akira Uruno
    • Masayuki Yamamoto
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14