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Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

Using phenotypic screening followed by optimization of side activities, the authors here identify pyrazolopyrimidine phosphodiesterase (PDE) inhibitors as anti-cryptosporidial drug leads. Humanizing a Cryptosporidum PDE by CRISPR indicates they target the parasite enzyme.

Jubilee Ajiboye
José E. Teixeira
Christopher D. Huston
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-16
A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Here, the authors provide a panel of medium-throughput assays to test potential drug candidates against different life cycle stages of Cryptosporidium with the goal to support a drug development pipeline that contains compounds with diverse molecular mechanisms of action.

Rajiv S. Jumani
Muhammad M. Hasan
Christopher D. Huston
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-14
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite development with good efficacy in murine and neonatal dairy calf disease models.

Christopher S. Lunde
Erin E. Stebbins
Christopher D. Huston
ResearchOpen Access27 Jun 2019
Nature Communications

Volume: 10, P: 1-11
Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness that associates with worse clinical outcomes.

Junru Wu
Anthony Cyr
Mieshia Beamon
ResearchOpen Access10 Nov 2022
Nature Communications

Volume: 13, P: 1-18

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Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

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Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

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