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Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Andrea Stojakovic et al. demonstrate that partial pharmacological inhibitor of mitochondrial complex I (CP2) can reduce neurodegeneration and improve key disease phenotypes in a symptomatic mouse model of Alzheimer’s disease.

Andrea Stojakovic
Sergey Trushin
Eugenia Trushina
ResearchOpen Access08 Jan 2021
Communications Biology

Volume: 4, P: 1-20
Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Noah Keller
Trace A. Christensen
Eugenia Trushina
ResearchOpen Access23 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites in serum.

Matthias Arnold
Kwangsik Nho
Gabi Kastenmüller
ResearchOpen Access02 Mar 2020
Nature Communications

Volume: 11, P: 1-12
Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

Liang Zhang
Sergey Trushin
Eugenia Trushina
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Andrea Stojakovic
Sergey Trushin
Eugenia Trushina
Amendments and CorrectionsOpen Access26 Feb 2024
Communications Biology

Volume: 7, P: 1-9
Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice

Shinwoo Kang
Jeyeon Lee
Doo-Sup Choi
ResearchOpen Access14 Oct 2024
Scientific Reports

Volume: 14, P: 1-19
Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models

Tetsushi Kataura
Lucia Sedlackova
Viktor I. Korolchuk
ResearchOpen Access31 May 2024
Cell Death & Disease

Volume: 15, P: 1-13
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Accumulating evidence indicates that impaired glucose metabolism in the brain is involved in the cause and progression of neurodegenerative disorders of ageing such as Alzheimer disease. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by rescuing, protecting or normalizing brain energetics.

Stephen C. Cunnane
Eugenia Trushina
Mark J. Millan
Reviews24 Jul 2020
Nature Reviews Drug Discovery

Volume: 19, P: 609-633

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Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice

Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

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