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Showing 101–150 of 496 results

Advanced filters: Author: Eun Sun Park Clear advanced filters

Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

Takehiro Takahashi
Mallory K. Ellingson
Akiko Iwasaki
Research22 Sept 2021
Nature

Volume: 597, P: E10-E11
ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51/PCNA regulation.

Su Hyung Park
Nalae Kang
Kyungjae Myung
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-15
Author Correction: The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

Chang Hoon Ji
Hee Yeon Kim
Yong Tae Kwon
Amendments and CorrectionsOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.

Alvaro N. Barbeira
Scott P. Dickinson
Hae Kyung Im
ResearchOpen Access08 May 2018
Nature Communications

Volume: 9, P: 1-20
From community to science to community, enhancing remote sensing of water quality in Chesapeake Bay tributaries through participatory science

Min-Sun Lee
Maria Tzortziou
Alison Cawood
ResearchOpen Access10 Aug 2025
Scientific Reports

Volume: 15, P: 1-20
Real-world data of dacomitinib as first-line treatment for patients with EGFR-mutant non-small-cell lung cancer

Ji Eun Shin
Hyun Ae Jung
Byoung Yong Shim
ResearchOpen Access07 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2^hi macrophages in infarcted hearts

Cellular composition and function are not clearly defined in heart failure after myocardial infarction. Here, using single cell and spatial transcriptomics in a MI-HF mouse model, the authors show that macrophages expressing Trem2 are found within the infarcts and this could be a useful biomarker.

Seung-Hyun Jung
Byung-Hee Hwang
Yeun-Jun Chung
ResearchOpen Access06 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Endothelial progenitor cell differentiation using cryopreserved, umbilical cord blood-derived mononuclear cells

Jun-ho Jang
Sun-kyung Kim
Hugh C Kim
Research01 Mar 2007
Acta Pharmacologica Sinica

Volume: 28, P: 367-374
Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis

Byeong Chang Sim
Yea Eun Kang
Hyon-Seung Yi
ResearchOpen Access21 Sept 2023
Cell Death & Disease

Volume: 14, P: 1-13
Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung

Young-Sam Lee
Jonghoe Byun
Duk-Kyung Kim
ResearchOpen Access01 Feb 2005
Experimental & Molecular Medicine

Volume: 37, P: 27-35
Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner

Mi Eun Lee
So Ra Kim
Jeong A Han
ResearchOpen Access06 Jul 2012
Experimental & Molecular Medicine

Volume: 44, P: 536-544
Therapy-induced senescent cancer cells contribute to cancer progression by promoting ribophorin 1-dependent PD-L1 upregulation

Conventional therapies can induce cancer cell senescence. Here the authors show that therapy-induced senescent cancer cells can escape T-cell immunity by upregulating PD-L1, whose expression and glycosylation levels are regulated by ribophorin 1.

Hyun Jung Hwang
Donghee Kang
Jae-Seon Lee
ResearchOpen Access03 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Hye-Won Lim
Suntaek Hong
Chang-Jin Lim
ResearchOpen Access01 Oct 2005
Experimental & Molecular Medicine

Volume: 37, P: 497-506
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

Genome-wide single-gene deletion libraries can be important tools for understanding the molecular workings of an organism, but have only been created for a single eukaryotic species, Saccharomyces cerevisiae. Now, Kim et al. present a second collection of deletion mutants that covers 98.4% of the genes of Schizosaccharomyces pombe, allowing a systematic comparison of gene essentiality and knockout phenotypes between two eukaryotic species.

Dong-Uk Kim
Jacqueline Hayles
Kwang-Lae Hoe
Research16 May 2010
Nature Biotechnology

Volume: 28, P: 617-623
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H₂O₂⁻ production

Chun et al. find that a severe model of reactive astrocytes overproduces hydrogen peroxide, leading to the development of Alzheimer’s disease-like pathologies, including neurodegeneration, tauopathy and memory impairment.

Heejung Chun
Hyeonjoo Im
C. Justin Lee
Research16 Nov 2020
Nature Neuroscience

Volume: 23, P: 1555-1566
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.

Scisung Chung
Mi-Sun Kang
Yunje Cho
ResearchOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1-14
Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to contribute to phosphorylation and aggregation of tau, including PIN1.

Jun Sung Park
Junehawk Lee
Jeong Ho Lee
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-12
The superoxide dismutase mimetic TEMPOL modulates nicotine-induced hyperlocomotor activity and nicotine-taking behavior in male rats

Kyung Oh Jeon
Jordan T. Yorgason
Eun Young Jang
ResearchOpen Access14 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
Identification of de novo EP300 and PLAU variants in a patient with Rubinstein–Taybi syndrome-related arterial vasculopathy and skeletal anomaly

Jong Eun Park
Eunmi Kim
Duk-Kyung Kim
ResearchOpen Access05 Aug 2021
Scientific Reports

Volume: 11, P: 1-9
Night-shift work, circadian and melatonin pathway related genes and their interaction on breast cancer risk: evidence from a case-control study in Korean women

Thu-Thi Pham
Eun-Sook Lee
Boyoung Park
ResearchOpen Access29 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Clinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome

Dong-Min Kim
Byung Jun Yu
Shilpa Chatterjee
ResearchOpen Access26 Apr 2023
Scientific Reports

Volume: 13, P: 1-5
Monolayer Kagome metals AV₃Sb₅

Much recent work has focused on the kagome metals AV₃Sb₅ (A = K, Rb, and Cs), but studies of the monolayer form are only just beginning. Here, the authors theoretically study monolayer kagome metals, and predict modified van Hove singularities that lead to charge-density-wave doublets and d-wave superconductivity.

Sun-Woo Kim
Hanbit Oh
Youngkuk Kim
ResearchOpen Access03 Feb 2023
Nature Communications

Volume: 14, P: 1-10
Clinical application of whole-genome sequencing of solid tumors for precision oncology

Ryul Kim
Seokhwi Kim
Minsuk Kwon
ResearchOpen Access13 Aug 2024
Experimental & Molecular Medicine

Volume: 56, P: 1856-1868
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction modulates the KRS-promoted metastatic potential of 67LR without disrupting the normal function of each protein.

Dae Gyu Kim
Jin Young Lee
Sunghoon Kim
Research10 Nov 2013
Nature Chemical Biology

Volume: 10, P: 29-34
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells

LRP1 plays a key role in the clearance of Aβ peptides across the blood-brain barrier. Here, the authors report that ANKS1A promotes the LRP1-mediated Aβ clearance in brain endothelium, providing insights into the pathology of Alzheimer’s disease.

Jiyeon Lee
Haeryung Lee
Soochul Park
ResearchOpen Access20 Dec 2023
Nature Communications

Volume: 14, P: 1-20
Human zinc fingers as building blocks in the construction of artificial transcription factors

Kwang-Hee Bae
Young Do Kwon
Jin-Soo Kim
Research18 Feb 2003
Nature Biotechnology

Volume: 21, P: 275-280
Dynamic increase of M2 macrophages is associated with disease progression of colorectal cancers following cetuximab-based treatment

Hyung-Don Kim
Sun Young Kim
Tae Won Kim
ResearchOpen Access31 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse

The formation of an immunological synapse is central to the ability of NK cells to lyse target cells. Here the authors show that Nogo receptor 1 (NgR1) might be a good target for cancer immunotherapy as it destabilizes the NK synapse, resulting in defective killing of tumor cells.

Se-Chan Oh
Seong-Eun Kim
Tae-Don Kim
Research09 Jan 2023
Nature Immunology

Volume: 24, P: 463-473
Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Espanola et al. show in zebrafish that Supt16h, a component of the FACT complex, regulates HSC development through an increase of p53, which promotes expression of phc1, a transcriptional repressor of Notch.

Sophia G. Espanola
Hyemin Song
Yoonsung Lee
Research23 Nov 2020
Nature Cell Biology

Volume: 22, P: 1411-1422
Precise base editing without unintended indels in human cells and mouse primary myoblasts

Da Eun Yoon
Na-Rae Kim
Kyoungmi Kim
ResearchOpen Access01 Dec 2023
Experimental & Molecular Medicine

Volume: 55, P: 2586-2595
Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells

Eun Jung Lee
Kyoung Jin Lee
Serk In Park
ResearchOpen Access21 Apr 2023
Bone Research

Volume: 11, P: 1-14
The globalizability of temporal discounting

Ruggeri et al. find in a study of 61 countries that temporal discounting patterns are globally generalizable. Worse financial environments, greater inequality and high inflation are associated with extreme or inconsistent long-term decisions.

Kai Ruggeri
Amma Panin
Eduardo García-Garzon
ResearchOpen Access11 Jul 2022
Nature Human Behaviour

Volume: 6, P: 1386-1397
Sex differences in immune responses that underlie COVID-19 disease outcomes

Male patients with COVID-19 have higher plasma levels of innate immune cytokines and chemokines such as IL-8, IL-18 and CCL5 and more non-classical monocytes than female patients, whereas female patients mount robust T cell activation maintained even in older age.

Takehiro Takahashi
Mallory K. Ellingson
Akiko Iwasaki
Research26 Aug 2020
Nature

Volume: 588, P: 315-320
Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD

Hyunjin Ryu
Yeji Hong
Kyoung Hwa Kim
ResearchOpen Access02 Mar 2023
Scientific Reports

Volume: 13, P: 1-11
Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians

Ching-Yu Cheng
Kenji Yamashiro
Chiea Chuen Khor
Amendments and Corrections30 Mar 2015
Nature Communications

Volume: 6, P: 1
Metabolic Biomarkers In Midtrimester Maternal Plasma Can Accurately Predict Adverse Pregnancy Outcome in Patients with SLE

Seung Mi Lee
Eun Mi Lee
Do Yup Lee
ResearchOpen Access23 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
The effect of a scenario-based cognitive behavioral therapy mobile app on end-stage kidney disease patients on dialysis

Dong-Seop Kim
Ho Sup Song
Eun Young Lee
ResearchOpen Access02 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Evidence of genetic progression in human gastric carcinomas with microsatellite instability

Yeun-Jun Chung
Sang-Won Park
Mun-Gan Rhyu
Research02 Oct 1997
Oncogene

Volume: 15, P: 1719-1726
FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell death

Byeong-Ju Kim
Sun Mi Hong
You-Sun Kim
ResearchOpen Access02 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-15
Multimodal AI model for preoperative prediction of axillary lymph node metastasis in breast cancer using whole slide images

Doohyun Park
Yong-Moon Lee
Dosik Hwang
ResearchOpen Access06 May 2025
npj Precision Oncology

Volume: 9, P: 1-13
Development of a patient-derived xenograft model of glioblastoma via intravitreal injection in mice

Jooyoung Lee
Dong Hyun Jo
Sun Ha Paek
ResearchOpen Access16 Apr 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-9
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane

The authors present the full-length dimeric TRIM72 E3 ubiquitin ligase and the architecture of its high-order assembly bound to a phosphatidylserine-enriched membrane, providing insights into its role in membrane repair and ubiquitylation.

Si Hoon Park
Juhyun Han
Hyun Kyu Song
ResearchOpen Access28 Sept 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1695-1706
Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria

Jung Eun Lee
Hansoo Park
Jeong-Sun Seo
ResearchOpen Access30 Apr 2009
Experimental & Molecular Medicine

Volume: 41, P: 253-258
TRPV1 inhibition overcomes cisplatin resistance by blocking autophagy-mediated hyperactivation of EGFR signaling pathway

The emergence of cisplatin resistance and side-effects are important factors in cancer treatment failure. Here, the authors identify autophagy-mediated EGFR hyperactivation by TRPV1 promotion as a mechanism of cisplatin resistance and demonstrate the efficacy of a TRPV1 inhibitor to sensitize lung cancer to cisplatin.

Se Jin Oh
Ji Yeon Lim
Tae Woo Kim
ResearchOpen Access10 May 2023
Nature Communications

Volume: 14, P: 1-17
Coordination tuning of cobalt phosphates towards efficient water oxidation catalyst

The role of metal-coordination environment on the effectiveness of water oxidation catalysts is relatively unexplored. Here, the authors study a range of cobalt phosphate catalysts with varying coordination environments and observe high activity and stability for a distorted tetrahedral cobalt system.

Hyunah Kim
Jimin Park
Kisuk Kang
ResearchOpen Access14 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Mesenchymal stem cells prevent the progression of diabetic nephropathy by improving mitochondrial function in tubular epithelial cells

Seung Eun Lee
Jung Eun Jang
Eun Hee Koh
ResearchOpen Access09 Jul 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-14
Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

Chronic stress induces maladaptive changes in the neural networks and it’s associated with mood disorders. Here, the authors show that repeated exposure to short-term stress can resolve pre-existing chronic stress induced depressive-like behaviour in mice.

Eun-Hwa Lee
Jin-Young Park
Pyung-Lim Han
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Reduction in limb-movement complexity at term-equivalent age is associated with motor developmental delay in very-preterm or very-low-birth-weight infants

Myung Woo Park
Hyung-Ik Shin
Woo Hyung Lee
ResearchOpen Access10 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor α-negative breast cancer cells to tamoxifen

Eun Ryoung Jang
Soo-Jeong Lim
Jong-Soo Lee
Research15 Dec 2003
Oncogene

Volume: 23, P: 1724-1736

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