Nerve damage in the peripheral nervous system induces spontaneous axon regeneration. Saijilafu et al.show that this regeneration requires phosphatidylinositol 3-kinase signalling, which activates glycogen synthase kinase 3 and the transcription factor Smad1, and not mammalian target of rapamycin or ß-catenin.
- Saijilafu
- Eun-Mi Hur
- Feng-Quan Zhou