Nature Search

Lmx1b is essential for the development of serotonergic neurons

Yu-Qiang Ding
Ulrika Marklund
Zhou-Feng Chen
Research03 Aug 2003
Nature Neuroscience

Volume: 6, P: 933-938
Serotonergic transcriptional programming determines maternal behavior and offspring survival

The central serotonergic system is an important modulator of neural circuitry that regulates behavior and emotion state of an animal. Current study from Lerch-Haner et al. shows that mutant female mice with defective serotonergic neurons exhibit gross maternal neglect resulting in offspring death, and that this defect can be rescued by expression of a homologous gene from human.

Jessica K Lerch-Haner
Dargan Frierson
Evan S Deneris
Research17 Aug 2008
Nature Neuroscience

Volume: 11, P: 1001-1003
Redefining the serotonergic system by genetic lineage

Patricia Jensen
Anna F Farago
Susan M Dymecki
Research16 Mar 2008
Nature Neuroscience

Volume: 11, P: 417-419
Maintenance of postmitotic neuronal cell identity

This Review discusses the molecular mechanisms by which neuronal identity is maintained throughout animals' development and lives. Drawing from the invertebrate and vertebrate literature, Deneris and Hobert also describe common themes, where the initial specification of neurons and subsequent maintenance of cell identity may share transcriptional programming and transcription factors. The piece also discusses such mechanism's implications for neurological diseases.

Evan S Deneris
Oliver Hobert
Reviews15 Jun 2014
Nature Neuroscience

Volume: 17, P: 899-907
A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Serotonin is released throughout the brain from diverse projections of neurons in the dorsal raphe nucleus. Here, the authors use optogenetics and fMRI mediated mapping of the mouse brain-wide serotonin network in response to acute stress and treatment with SSRI.

Joanes Grandjean
Alberto Corcoba
Bechara J. Saab
ResearchOpen Access21 Jan 2019
Nature Communications

Volume: 10, P: 1-10
Author Correction: A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Joanes Grandjean
Alberto Corcoba
Bechara J. Saab
Amendments and CorrectionsOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1
Pet-1 is required across different stages of life to regulate serotonergic function

Fev is an ETS transcription factor essential for the generation of serotonin neurons. This study reports that ongoing Fev-directed transcription is required at different stages of life for multiple regulatory events that shape and maintain the serotonergic system. Furthermore, behavioral alterations can result from adult-onset perturbation of serotonergic transcription.

Chen Liu
Takashi Maejima
Evan S Deneris
Research05 Sept 2010
Nature Neuroscience

Volume: 13, P: 1190-1198
Serotonergic transcriptional networks and potential importance to mental health

This review surveys the latest advances in the intrinsic regulatory programs directing the development and maintenance of vertebrate serotonin neurons. A new model of the regulatory program comprising a dynamic network of transcription factors is presented. The authors discuss the potential importance of network regulatory dysfunction in neuropsychiatric disorders.

Evan S Deneris
Steven C Wyler
Reviews26 Feb 2012
Nature Neuroscience

Volume: 15, P: 519-527
A transient placental source of serotonin for the fetal forebrain

Alexandre Bonnin
Nick Goeden
Pat Levitt
Research20 Apr 2011
Nature

Volume: 472, P: 347-350
Transcriptional Control of Serotonin-Modulated Behavior and Physiology

Chen Liu
Evan S Deneris
Research30 Nov 2010
Neuropsychopharmacology

Volume: 36, P: 361-362
RGS2 drives male aggression in mice via the serotonergic system

Melanie Mark et al demonstrate that RGS2, a protein associated with stress disorders, drives male aggression through the serotonergic system. They show that exogenous expression of RGS2 in serotogenic neurons augments aggression in male mice and rescues the docile phenotype of Rgs2 knockouts but does not affect anxiety.

Melanie D. Mark
Patric Wollenweber
Stefan Herlitze
ResearchOpen Access11 Oct 2019
Communications Biology

Volume: 2, P: 1-17
Mechanisms of transcriptional memory

Nicole J. Francis
Robert E. Kingston
Reviews01 Jun 2001
Nature Reviews Molecular Cell Biology

Volume: 2, P: 409-421
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

Prem N Yadav
Atheir I Abbas
Bryan L Roth
Research03 Nov 2010
Neuropsychopharmacology

Volume: 36, P: 638-651

Search

Lmx1b is essential for the development of serotonergic neurons

Serotonergic transcriptional programming determines maternal behavior and offspring survival

Redefining the serotonergic system by genetic lineage

Maintenance of postmitotic neuronal cell identity

A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Author Correction: A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Pet-1 is required across different stages of life to regulate serotonergic function

Serotonergic transcriptional networks and potential importance to mental health

A transient placental source of serotonin for the fetal forebrain

Transcriptional Control of Serotonin-Modulated Behavior and Physiology

RGS2 drives male aggression in mice via the serotonergic system

Mechanisms of transcriptional memory

The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy

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