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Showing 1–3 of 3 results
Advanced filters: Author: Evangelia Darai Clear advanced filters

  • Metabolism plays an important role in response to DNA damage, however the underlying mechanisms are less clear. Here, the authors identify a non-canonical role of IMPDH2 wherein it is recruited to the chromatin following DNA damage and mediates PARP1-dependent DNA damage repair via the regulation of nuclear NAD+ levels.

    • Lorena Espinar
    • Marta Garcia-Cao
    • Sara Sdelci
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • The nuclear localization of metabolic enzymes is fascinating and in most cases remains a mystery. Here, Pardo Lorente and colleagues show that nuclear MTHFD2 is required for successful mitosis by controlling centromeric histone methylation.

    • Natalia Pardo-Lorente
    • Anestis Gkanogiannis
    • Sara Sdelci
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • On-site diagnostics technologies allow for rapid, cost-effective diagnosis with a particular importance for remote communities. Here the authors demonstrate the use of mobile phone based microscopy for targeted DNA sequencing andin situpoint mutation detection in tumours.

    • Malte Kühnemund
    • Qingshan Wei
    • Mats Nilsson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8