Chronic diarrhoea induced by bile acids is common and the underlying mechanisms are linked to homeostatic regulation of hepatic bile acid synthesis by fibroblast growth factor 19 (FGF19). This Review first concentrates on studies that have investigated different methods to increase recognition and diagnosis of bile-acid-induced diarrhoea, before describing further evidence for a role of FGF19 and logical steps to improve treatment, related to findings with FGF19.
