Wu et al. report that MED16, a novel component of the MYC2–MED25 functional complex in Arabidopsis, stabilizes MED25 by competing with MED25-BINDING RING-H2 PROTEIN1 (MBR1) and MBR2 for binding to the vWF-A domain of MED25, thereby preventing its degradation and activating JA-responsive gene expression.
- Fangming Wu
- Chuanlong Sun
- Chuanyou Li