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Detection of minor drug-resistant populations by parallel allele-specific sequencing

Fangping Cai
Haifeng Chen
Feng Gao
Research07 Jan 2007
Nature Methods

Volume: 4, P: 123-125
Correction: Corrigendum: Detection of minor drug-resistant populations by parallel allele-specific sequencing

Fangping Cai
Haifeng Chen
Feng Gao
Amendments and Corrections01 Feb 2007
Nature Methods

Volume: 4, P: 187
Using arterial–venous analysis to characterize cancer metabolic consumption in patients

Cellular metabolism is altered in many cancer types and the advent of metabolomics has allowed us to understand more about how this is dysregulated. Here, the authors report a method named CARVE to analyse the arterial supply and venous drainage of glioma patients during surgery and identify the metabolites that may be consumed and produced by the cancer.

Nanxiang Xiong
Xiaofei Gao
Woo-ping Ge
ResearchOpen Access23 Jun 2020
Nature Communications

Volume: 11, P: 1-9
HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8⁺ T-cell infiltration into tumors

Lack of CD8⁺ T-cell infiltration into solid tumors is associated with poor responsiveness to immune checkpoint therapy (ICT). Here, the authors show that blocking the phosphorylation of HRS to reduce the induction of immunosuppressive exosomes promotes CD8⁺ T-cell infiltration into tumors and enhances the efficacy of ICT in mouse melanoma models.

Lei Guan
Bin Wu
Wei Guo
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-12
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Immunization of macaques with nanoparticle-conjugated receptor-binding domain of SARS-CoV-2 adjuvanted with 3M-052 and alum results in cross-neutralizing antibodies against bat coronaviruses, SARS-CoV and SARS-CoV-2 variants, and may provide a platform for developing pan-coronavirus vaccines.

Kevin O. Saunders
Esther Lee
Barton F. Haynes
Research10 May 2021
Nature

Volume: 594, P: 553-559
Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

Recombination contributes to HIV evolution in patients, but its identification can be difficult. Here, the authors develop a computational tool called RAPR to track recombination in patients, identify recombination hot spots, and show contribution of recombination to antibody escape.

Hongshuo Song
Elena E. Giorgi
Feng Gao
ResearchOpen Access15 May 2018
Nature Communications

Volume: 9, P: 1-15
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Longitudinal sampling is used to map the evolution of an HIV-1 virus from the time of infection, and the co-evolution of a broadly neutralizing antibody in the same infected patient; the findings have important implications for HIV vaccine development.

Hua-Xin Liao
Rebecca Lynch
Barton F. Haynes
Research03 Apr 2013
Nature

Volume: 496, P: 469-476
Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences

Hongshuo Song
Bhavna Hora
Feng Gao
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-13

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