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Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism.

Kenneth C. P. Cheung
Silvia Fanti
Federica M. Marelli-Berg
ResearchOpen Access17 Jul 2020
Nature Communications

Volume: 11, P: 1-18
Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Hongmei Fu
Juho Vuononvirta
Federica M. Marelli-Berg
Amendments and CorrectionsOpen Access25 Feb 2025
Nature Metabolism

Volume: 7, P: 634
The glucose transporter 2 regulates CD8⁺ T cell function via environment sensing

In this study, Fu et al. provide mechanistic insight into how GLUT2 fine-tunes environmental nutrient sensing with T cell activation, which optimizes metabolic adaptation during acquisition of T cell effector function.

Hongmei Fu
Juho Vuononvirta
Federica M. Marelli-Berg
ResearchOpen Access26 Oct 2023
Nature Metabolism

Volume: 5, P: 1969-1985
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation

Regulatory T cells (Tregs) are important for the maintenance of self-tolerance and this requires their trafficking to the lymph nodes and target tissues. Here, the authors show that the recognition of self-antigens expressed by endothelial cells in target tissue is instrumental for efficient Treg recruitment in vivo.

Hongmei Fu
Madhav Kishore
Federica M. Marelli-Berg
ResearchOpen Access14 Mar 2014
Nature Communications

Volume: 5, P: 1-14
Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation

Vyas et al. show that epicardial adipose tissue is a reservoir for a subpopulation of tissue-resident memory T cells that can increase the vulnerability of the heart to atrial fibrillation.

Vishal Vyas
Balraj Sandhar
M. Paula Longhi
ResearchOpen Access23 Aug 2024
Nature Cardiovascular Research

Volume: 3, P: 1067-1082
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the discovery of patient-specific mechanisms of disease and the identification of effective drugs

Claire Vinel
Gabriel Rosser
Silvia Marino
ResearchOpen Access21 Oct 2021
Nature Communications

Volume: 12, P: 1-20
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

James I. Elliott
Annmarie Surprenant
Christopher F. Higgins
Research17 Jul 2005
Nature Cell Biology

Volume: 7, P: 808-816
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.

Fabrizia Bonacina
David Coe
Giuseppe D. Norata
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Immunometabolic mechanisms of heart failure with preserved ejection fraction

Joseph A. Hill and colleagues discuss basic and translational data focusing on the most common form of heart failure with preserved ejection fraction (HFpEF), cardiometabolic HFpEF, emphasizing the bidirectional cross-talk between metabolic dysregulation triggering immune events—and vice versa—in syndrome pathogenesis.

Gabriele G. Schiattarella
Pilar Alcaide
Joseph A. Hill
Reviews14 Mar 2022
Nature Cardiovascular Research

Volume: 1, P: 211-222
HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids

Elizabeth G. Wood
Claire E. Macdougall
M. Paula Longhi
ResearchOpen Access30 Nov 2020
Scientific Reports

Volume: 10, P: 1-12

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