Aldolase A is one of the glycolytic enzymes that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an ATP-consuming process. Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic metabolic plasticity of cancer cells.
- Luiza Martins Nascentes Melo
- Feyza Cansiz
- Alpaslan Tasdogan
