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Advanced filters: Author: Fiona D. Ehrich Clear advanced filters

Scalable topic modelling decodes spatial tissue architecture for large-scale multiplexed imaging analysis

Peng and colleagues present SpatialTopic, a scalable computational method that decodes spatial tissue structure from large-scale multiplexed images, thereby enabling rapid, integrative analysis of millions of cells across multiple tissue slides.

Xiyu Peng
James W. Smithy
Ronglai Shen
ResearchOpen Access18 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues

Denis Filisetti
Georg Ostermann
Claudine Oudet
Research22 Jun 1999
European Journal of Human Genetics

Volume: 7, P: 615-619
HIV immune evasin Nef enhances allogeneic CAR T cell potency

HIV-1 immune evasin Nef reduces activation-induced cell death and promotes survival of chimeric antigen receptor (CAR) T cells; thus, virus-like immune escape enhances therapeutic efficacy of allogeneic CAR T cells.

Karlo Perica
Ivan S. Kotchetkov
Michel Sadelain
Research30 Jan 2025
Nature

Volume: 640, P: 793-801

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Scalable topic modelling decodes spatial tissue architecture for large-scale multiplexed imaging analysis

Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues

HIV immune evasin Nef enhances allogeneic CAR T cell potency

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