Etienne-Manneville and colleagues demonstrate that the adherens junctions of adjacent migrating cultured cells exhibit retrograde flow along the lateral cell sides. They show that the rearward treadmilling of junctions is followed by N-cadherin endocytosis at the cell rear and anterograde trafficking to support formation of new junctional complexes at the cell front.
- Florent Peglion
- Flora Llense
- Sandrine Etienne-Manneville