Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide, and is associated with the metabolic syndrome. This Review discusses the mechanisms involved in hepatic steatosis and inflammation—the two steps of liver injury in NAFLD. The authors also discuss the role of fructose in the development of both NAFLD and the metabolic syndrome.
- Jung Sub Lim
- Michele Mietus-Snyder
- Robert H. Lustig
