David Modiano and colleagues report an epidemiological study examining the role of host genetic variation at the β-globin locus on transmission of malaria in cross-sectional and transmission surveys from West Africa. They find that individuals carrying HbC allele show increased gametocyte levels, and an increased rate of Plasmodium falciparum transmission to the Anopheles vector.
- Louis Clement Gouagna
- Germana Bancone
- David Modiano