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Advanced filters: Author: Fu-rong Qiu Clear advanced filters

Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro

Jin Zeng
Yu-juan Fan
Fu-rong Qiu
Research08 Feb 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1393-1404
First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors

PIK3CA is a commonly mutated cancer-associated gene, making it an attractive therapeutic target. Here, the authors report the results of a first-in-human phase Ia trial to assess the safety and recommended phase II dose of CYH33, a PI3Kα inhibitor, in patients with advanced solid tumors.

Xiao-Li Wei
Fu-Rong Liu
Rui-Hua Xu
ResearchOpen Access16 Nov 2022
Nature Communications

Volume: 13, P: 1-10

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Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro

First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors

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