Nature Search

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.

Natalie A. Afshari
Robert P. Igo Jr
Sudha K. Iyengar
ResearchOpen Access30 Mar 2017
Nature Communications

Volume: 8, P: 1-8
Fuchs' heterochromic cyclitis and retinal vascular abnormalities in progressive hemifacial atrophy

Ellen La Hey
G Seerp Baarsma
Research01 May 1993
Eye

Volume: 7, P: 426-428
Lazarus Fuchs

G. B. M.
News12 Jun 1902
Nature

Volume: 66, P: 156-157
A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation

A multi-ancestry GWAS meta-analysis of Fuchs endothelial corneal dystrophy identifies eight novel loci, including low-frequency missense variants in laminin genes LAMA5 and LAMB1, and phenome-wide scans uncover pleiotropy with renal traits at TCF4.

Bryan R. Gorman
Michael Francis
Sudha K. Iyengar
ResearchOpen Access06 Apr 2024
Communications Biology

Volume: 7, P: 1-12
Fuchs’ Endothelial Corneal Dystrophy evaluation using a high-resolution wavefront sensor

Carolina Belda-Para
Gonzalo Velarde-Rodríguez
José M. Rodríguez-Ramos
ResearchOpen Access02 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy

Inhibition of ATM in corneal endothelial cells restores DNA repair in G2/M phase of the cell cycle and attenuates senescence under chronic stress in FECD.

Shazia Ashraf
Neha Deshpande
Ula V. Jurkunas
ResearchOpen Access10 Nov 2024
Communications Biology

Volume: 7, P: 1-13
Reply to Fuchs fuchs Fuch’s and Fuchs’!

G R J Melles
Correspondence21 Feb 2014
Eye

Volume: 28, P: 636
Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy

Peipei Pan
Daniel J. Weisenberger
Matilda F. Chan
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
What does the future hold for the treatment of Fuchs endothelial dystrophy; will ‘keratoplasty’ still be a valid procedure?

M Bruinsma
C M Tong
G R J Melles
Research12 Jul 2013
Eye

Volume: 27, P: 1115-1122
Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling

Exercise promotes recovery after stroke, but the underlying mechanisms are unclear. Here, the authors show that regulatory T cells enable exercise-induced repair by reducing neuronal hyperexcitability via interleukin-10, linking immunity to functional regeneration.

A. Schmidt-Pogoda
T. Ruck
J. Minnerup
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy: review of the first 50 consecutive cases

L Ham
I Dapena
G R J Melles
Research30 Jan 2009
Eye

Volume: 23, P: 1990-1998
Author Correction: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy

Peipei Pan
Daniel J. Weisenberger
Matilda F. Chan
Amendments and CorrectionsOpen Access06 Feb 2020
Scientific Reports

Volume: 10, P: 1
Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies

A gene therapy method using AAV can help deliver HIV-fighting antibodies long-term, but the body often rejects them. Here the authors show that a short course of the drug rapamycin helps prevent host anti-drug antibody responses, showing successful antibody delivery in mice and monkeys.

Sebastian P. Fuchs
Paula G. Mondragon
Ronald C. Desrosiers
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Scaling of proton acceleration driven by petawatt-laser–plasma interactions

L. Robson
P. T. Simpson
P. McKenna
Research10 Dec 2006
Nature Physics

Volume: 3, P: 58-62
Effect of modification by N-acetoxy-N-2-acetylaminofluorene on the level of DNA methylation

C. E. SALAS
A. PFOHL-LESZKOWICZ
M. C. LANG
Research01 Mar 1979
Nature

Volume: 278, P: 71-72
A missense mutation in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa

Angela M. Christiano
Daniel S. Greenspan
Jouni Uitto
Research01 May 1993
Nature Genetics

Volume: 4, P: 62-66
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

Alexander Teumer
Yong Li
Anna Köttgen
ResearchOpen Access11 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Linkage of epidermolytic hyperkeratosis to the type II keratin gene cluster on chromosome 12q

John G. Compton
John J. DiGiovanna
Sherri J. Bale
Research01 Jul 1992
Nature Genetics

Volume: 1, P: 301-305
Corneal guttata: A comparative clinical and specular micrographic study

A J Jackson
F O Robinson
D B Archer
Research01 Nov 1999
Eye

Volume: 13, P: 737-743
Cell Metabolism During Melanophore Activity

MANFRED E. A. FUCHS
ROBERT G. A. LOTZ
Research01 Oct 1966
Nature

Volume: 212, P: 39-40
Engineering near-infrared single-photon emitters with optically active spins in ultrapure silicon carbide

Single-photon quantum emitters with optically active spins are desirable for quantum information processing, secure networks and nanosensing, but engineering of these spin centres has been challenging. Here, Fuch et al. demonstrate the control of spin centre density in silicon carbide over eight orders of magnitude.

F. Fuchs
B. Stender
G. V. Astakhov
Research07 Jul 2015
Nature Communications

Volume: 6, P: 1-7
Antarctic Crevasse Accident

J. T. BAILEY
D. P. WILD
G. DE Q. ROBIN
Research01 Jan 1966
Nature

Volume: 209, P: 18-19
Succession of Cainozoic Vertebrate Assemblages from the Northern Kenya Rift Valley

W. W. BISHOP
G. R. CHAPMAN
J. A. MILLER
Research08 Oct 1971
Nature

Volume: 233, P: 389-394
Further Inherent Characters of Plant Species of Wetter and Drier Habitats

M. L. R. PETTERSSON
G. E. J. GRAY
Research16 Aug 1958
Nature

Volume: 182, P: 450-451
Rifting, crustal attenuation and subsidence in the Bay of Biscay

O. de Charpal
P. Guennoc
D. G. Roberts
Research26 Oct 1978
Nature

Volume: 275, P: 706-711
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

A method termed ac⁴C-seq is introduced for the transcriptome-wide mapping of the RNA modification N⁴-acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.

Aldema Sas-Chen
Justin M. Thomas
Schraga Schwartz
Research17 Jun 2020
Nature

Volume: 583, P: 638-643
Towards gene therapy for haemophilia B using primary human keratinocytes

Ann J. Gerrard
David L. Hudson
Fiona M. Watt
Research01 Feb 1993
Nature Genetics

Volume: 3, P: 180-183
Mechanism of Inhibitory Action of Histones on DNA Template Activity in vitro

YU. V. KOSLOV
G. P. GEORGIEV
Research17 Oct 1970
Nature

Volume: 228, P: 245-247
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient

Antibodies against SARS-CoV-2 can be used to treat infections but there is a risk of driving viral resistance to antibodies. Here the authors characterise SARS-CoV-2 escape mutants from an immunocompromised patient treated with anti-SARS-CoV-2 antibodies using mouse protection studies and structural prediction.

Lena Jaki
Sebastian Weigang
Jonas Fuchs
ResearchOpen Access10 Apr 2023
Nature Communications

Volume: 14, P: 1-14
'Domestic' origin of opaque assemblages in refractory inclusions in meteorites

Joel D. Blum
G.J. Wasserburg
Edward M. Stolper
Research04 Feb 1988
Nature

Volume: 331, P: 405-409
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Guinea Pig Kallikrein System

G. E. DAVIES
J. S. LOWE
Research06 Apr 1963
Nature

Volume: 198, P: 94-95
Results of the Occultation of Regulus by Venus, July 7, 1959

G. de VAUCOULEURS
D. H. MENZEL
Research01 Oct 1960
Nature

Volume: 188, P: 28-33
A Ligand Exclusion Theory of Allosteric Effects

HARVEY F. FISHER
RONALD E. GATES
DALLAS G. CROSS
Research17 Oct 1970
Nature

Volume: 228, P: 247-249
Occurrence of Citrulline in Proteins

G. E. ROGERS
Research23 Jun 1962
Nature

Volume: 194, P: 1149-1151
Timing of the photoperiod and the hour of birth in rats

DENNIS W. LINCOLN
DAVID G. PORTER
Research01 Apr 1976
Nature

Volume: 260, P: 780-781
Hydration of Metal Cations

E. GLUECKAUF
G. P. KITT
Research06 Jun 1953
Nature

Volume: 171, P: 1010-1012
Genetic and Developmental Studies of a Quantitative Character

S. G. SPICKETT
Research31 Aug 1963
Nature

Volume: 199, P: 870-873
Sexing of Live Rabbit Blastocysts

R. G. EDWARDS
R. L. GARDNER
Research06 May 1967
Nature

Volume: 214, P: 576-577
YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution

The molecular mechanisms underlying tumour initiation remain elusive. Here, the authors use spatiotemporally controlled oncogene activation and tumour suppressor inhibition with multi-omics to unveil the role of YAP-mediated oral epithelial progenitor cell reprogramming into tumour-initiating cells.

Farhoud Faraji
Sydney I. Ramirez
J. Silvio Gutkind
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Palladium-catalysed cross-coupling of lithium acetylides

The Sonogashira cross-coupling is a key strategy in modern synthesis for C–C bond formation and introduction of the versatile alkyne functionality into organic molecules. Now, a complementary method is reported based on the palladium-catalysed cross-coupling of lithium acetylides with aryl bromides.

Hugo Helbert
Paco Visser
Ben L. Feringa
Research13 Jul 2020
Nature Catalysis

Volume: 3, P: 664-671
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

Xin et al. show, through intravital imaging, that Kras^G12D induces epithelial tissue deformation in a spatiotemporally specific manner by converting the pulsatile ERK signal fluctuation in stem cells into sustained activation.

Tianchi Xin
Sara Gallini
Valentina Greco
Research30 Apr 2024
Nature Cell Biology

Volume: 26, P: 859-867
Immunosuppressants in patients with AIDS

A. HAUSEN
M.P. DIERICH
H. WACHTER
Research13 Mar 1986
Nature

Volume: 320, P: 114
Enzymatic Birch reduction via hydrogen atom transfer at [4Fe-4S]-OH₂ and [8Fe-9S] clusters

Class I and II benzoyl-coenzyme A reductases offer a mild biological alternative to the alkali metal- and ammonia-dependent Birch reduction, a classical synthetic method for achieving dihydro additions to arenes. Here, the authors characterize double-cubane [8Fe-9S] and active site aqua-[4Fe-4S] clusters of a class I benzoyl-CoA reductase and provide evidence for a radical mechanism.

Jonathan Fuchs
Unai Fernández-Arévalo
Matthias Boll
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Evolution of the lower continental crust: granulite facies xenoliths from the Eifel, West Germany

H.-G. Stosch
G. W. Lugmair
Research27 Sept 1984
Nature

Volume: 311, P: 368-370
Translation from unconventional 5′ start sites drives tumour initiation

The translation of upstream open reading frames in skin tumour models protects some cancer-related mRNAs from global reductions in protein synthesis during the early stages of tumour initiation, suggesting that unconventional translation has a crucial role in tumorigenesis.

Ataman Sendoel
Joshua G. Dunn
Elaine Fuchs
Research11 Jan 2017
Nature

Volume: 541, P: 494-499
Spatial multiomic landscape of the human placenta at molecular resolution

The spatial single-cell multiomic atlas of the first trimester human placenta at molecular resolution provides a blueprint for future studies on early placental development and pregnancy.

Johain R. Ounadjela
Ke Zhang
Jian Shu
Research20 Nov 2024
Nature Medicine

Volume: 30, P: 3495-3508
Addition of Osmium Tetroxide to Dinaphthylethylenes

G. M. BADGER
Research22 Apr 1950
Nature

Volume: 165, P: 647-649
Room-temperature quantum microwave emitters based on spin defects in silicon carbide

Defects in silicon carbide can produce continuous-wave microwaves at room temperature. Spectroscopic analysis indicates a photoinduced inversion of the population in the spin ground states, which makes the defects a potential route to stimulated amplification of microwave radiation.

H. Kraus
V. A. Soltamov
G. V. Astakhov
Research08 Dec 2013
Nature Physics

Volume: 10, P: 157-162
Optical Properties of Bismuth

H. D. MALLON
I. G. RUNCIMAN
Research28 May 1960
Nature

Volume: 186, P: 709-710

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