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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Bulk vanadium dioxide undergoes a metal–insulator transition near room temperature. It is now shown that by putting a thin layer of vanadium dioxide on a buffer, and varying the buffer’s thickness, the orbital occupancy in the metallic state and the transition temperature can be tuned.

An important role is played by thermal effects in the electrically driven insulator-to-metal transition in V₂O₃.

Here, explainable deep learning and climate networks give insight into the dependencies between El Niño and river flow, with implications for machine learning-based earth system model coupling and climate-informed projections of water resources.

Phase segregation in mixed halide perovskite is known to alter the optoelectronic properties, but how it affects charge carriers is not clear. Here, the authors use THz spectroscopy to reveal that high carrier mobilities are well preserved, while recombination dynamics is affected by charge funnelling upon segregation.

Owing to its very low magnetization, small currents suffice to write a ferrimagnetic Heusler memory layer in complementary metal–oxide–semiconductor-compatible magnetic tunnel via spin-transfer torque, which can help in shrinking the memory cell and extending the application space for magnetic random-access memory.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

In biological processes, peptide bonds are formed via reactive phosphate-containing intermediates, facilitated by compartmentalized environments. Here, the authors use aminoacyl phosphate esters that drive selective peptide bond formation through side chain-controlled reactivity and self-assembly, resulting in the preferential incorporation of positively charged amino acids from mixtures containing natural and non-natural amino acids.

Pseudo-halide anion engineering is an effective surface passivation strategy for perovskite-based optoelectronics but the large chemical space of molecules limits its potential. Here, the authors create a machine learning workflow to find optimized pseudo-halide anions, which are verified in devices with improved performances.

The insurance hypothesis posits that more diverse communities are more stable through time. Here, the authors show that plant biodiversity reduces the spatial variability of productivity in grassland communities, demonstrating that the insurance hypothesis applies also across space.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.

All-perovskite triple-junction solar cell devices have been fabricated, with a certified efficiency of 23.3%; these devices retain 80% of their initial efficiency following 420 hours of operation.

The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumors for organoids and single-cell RNA-seq, and show the efficacy of PARP inhibitor combination treatments.

In this disease mapping study, the authors estimate disability-adjusted life year rates for three of the major causes of mortality for children under five 43 countries in sub-Saharan Africa. They identify significant heterogeneity at the subnational level, highlighting the need for a targeted intervention approach.

Evidence synthesized from 252 large-herbivore exclusion studies suggests that herbivore-induced change in dominance, independent of site productivity or precipitation, best predicts herbivore effects on biodiversity in grassland and savannah sites.

A CD8-specific, one-armed antibody positron emission tomography tracer enables the visualization of the immune response in patients with solid tumors before and after starting immunotherapy.

Flash Joule heating of inexpensive carbon sources is used to produce gram-scale quantities of high-quality graphene in under a second, without the need for a furnace, solvents or reactive gases.

It remains unclear whether exotic and native species are functionally different. Using a global grassland experiment, Seabloomet al. show that native and exotic species respond differently to two globally pervasive environmental changes, addition of mineral nutrients and alteration of herbivore density.

Analyses of the proportions of individuals who have completed key levels of schooling across all low- and middle-income countries from 2000 to 2017 reveal inequalities across countries as well as within populations.

Heusler alloy thin films with a distorted tetragonal structure have potential spintronics applications given their bulk perpendicular magnetic anisotropy. Here, the authors demonstrate large perpendicular magnetic anisotropy in Mn₃Ge thin films accompanied by negative tunnelling magnetoresistance.

Rhenium chalcohalide cluster compounds are promising photoluminescent materials. Here the authors report a new material in this family, Rb₆Re₆S₈I₈, which shows broad photoluminescence (PL) range, high PL quantum yield and long PL lifetime.

Heusler compounds are of great interest for spintronic applications. Here the authors report current driven domain wall motion in unit cell thick perpendicularly magnetized Heusler films with low current densities and show the velocity is dominated by the bulk chiral Dzyaloshinskii–Moriya exchange interaction.

Micelles find applications in areas such as drug delivery systems, and as such, the kinetic stability of these structures is of high interest. Here the authors show that individual block copolymer micelles can continue to evolve after transfer to a selective solvent.

Influenza A H1N1/2009 virus emerged from swine and rapidly replaced the seasonal H1N1 virus. Here, the authors show that natural selection acting on H1N1/2009 after introduction into humans was driven by adaptation to the new host but later selection has been driven by immunological escape.