Nature Search

Cellular and genetic mechanisms that shape the development and evolution of tail vertebral proportion in mice and jerboas

Vertebra lengths differ from the neck to the tail tip and differ between species, evidenced by extreme differences in mouse and jerboa tails. Here, Weber and colleagues identify cellular mechanisms and candidate genes that shape vertebral proportion.

Ceri J. Weber
Alexander J. Weitzel
Kimberly L. Cooper
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Natural selection for energetic efficiency and the relationship between activity level and mortality

I. G. PRIEDE
Research16 Jun 1977
Nature

Volume: 267, P: 610-611
National identity predicts public health support during a global pandemic

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Evidence from neodymium isotopes for mantle contributions to Phanerozoic crustal genesis in the Canadian Cordillera

Scott D. Samson
William C. McClelland
Robert G. Anderson
Research23 Feb 1989
Nature

Volume: 337, P: 705-709
Nature of the charge carriers in electron-doped copper oxide superconductors

J. M. Tranquada
S. M. Heald
M. Croft
Research23 Feb 1989
Nature

Volume: 337, P: 720-721
Natural History Museums

G. A. LEBOUR
Research20 Oct 1870
Nature

Volume: 2, P: 493
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Mild functional effects of a novel GFAP mutant allele identified in a familial case of adult-onset Alexander disease

Tiziana Bachetti
Francesco Caroli
Isabella Ceccherini
Research16 Jan 2008
European Journal of Human Genetics

Volume: 16, P: 462-470
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Naturally occurring tumours in the basal metazoan Hydra

The evolutionary origin of tumours remains largely unknown. Here, Domazet-Lošo et al. show evidence for naturally occurring tumours in the freshwater polyp, Hydra, and suggest that tumours have deep evolutionary roots.

Tomislav Domazet-Lošo
Alexander Klimovich
Thomas C.G. Bosch
Research24 Jun 2014
Nature Communications

Volume: 5, P: 1-8
Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies

A gene therapy method using AAV can help deliver HIV-fighting antibodies long-term, but the body often rejects them. Here the authors show that a short course of the drug rapamycin helps prevent host anti-drug antibody responses, showing successful antibody delivery in mice and monkeys.

Sebastian P. Fuchs
Paula G. Mondragon
Ronald C. Desrosiers
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study

The SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.

Michelle D. Pang
Louise Kjølbæk
Anne Raben
ResearchOpen Access07 Oct 2025
Nature Metabolism

P: 1-26
Native American gene flow into Polynesia predating Easter Island settlement

Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

Alexander G. Ioannidis
Javier Blanco-Portillo
Andrés Moreno-Estrada
Research08 Jul 2020
Nature

Volume: 583, P: 572-577
Fourier-based three-dimensional multistage transformer for aberration correction in multicellular specimens

Adaptive optical vision Fourier transformer (AOViFT) is a machine learning-based framework for accurately inferring aberrations and restoring diffraction-limited performance in diverse biological specimens.

Thayer Alshaabi
Daniel E. Milkie
Eric Betzig
ResearchOpen Access01 Oct 2025
Nature Methods

Volume: 22, P: 2171-2179
Natural History

G. M. V.
Books & Arts30 Jan 1937
Nature

Volume: 139, P: 175
Increasing tree size across Amazonia

A global research network monitoring the Amazon for 30 years reports in this study that tree size increased by 3% each decade.

Adriane Esquivel-Muelbert
Rebecca Banbury Morgan
Oliver L. Phillips
ResearchOpen Access25 Sept 2025
Nature Plants

P: 1-10
Tribute to Prof. Alexander Lipschutz

G. I. M. SWYER
News15 May 1954
Nature

Volume: 173, P: 902-903
Dr. Alexander Wood

G. F. C. SEARLE
Comments & Opinion17 Jun 1950
Nature

Volume: 165, P: 956
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Nelson H. Knudsen
Giulia Escobar
Marcela V. Maus
Research24 Sept 2025
Nature

P: 1-10
Alexander the Great and His Celestial Journey

G. GREENHILL
News13 Jun 1918
Nature

Volume: 101, P: 292-293
A systematic review and meta-analysis of GFAP gene variants in Alexander disease

Alice Grossi
Francesca Rosamilia
Tiziana Bachetti
ResearchOpen Access17 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
Dr. Alexander Macfarlane

C. G. KNOTT
News25 Sept 1913
Nature

Volume: 92, P: 103-104
Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic

Enterololin is a narrow-spectrum antibiotic that selectively kills Enterobacteriaceae in vitro and in a mouse model of adherent-invasive Escherichia coli gut infection. AI-guided mechanism-of-action studies identified LolCDE as its molecular target.

Denise B. Catacutan
Vian Tran
Jonathan M. Stokes
Research03 Oct 2025
Nature Microbiology

P: 1-15
A History of Later Greek Literature: from the Death of Alexander in 323 BC to the Death of Justinian in 565 AD

T. G.
Books & Arts20 Aug 1932
Nature

Volume: 130, P: 262
Foundation model for efficient biological discovery in single-molecule time traces

META-SiM brings foundation model power to single-molecule time traces, excelling across diverse analysis tasks. Paired with the web-based META-SiM Projector and entropy mapping, it rapidly reveals hidden molecular behaviors inaccessible by other means.

Jieming Li
Leyou Zhang
Nils G. Walter
Research02 Oct 2025
Nature Methods

Volume: 22, P: 2149-2160
HippoMaps: multiscale cartography of human hippocampal organization

HippoMaps provides an open-source resource for studying the human hippocampus at different scales and with different modalities such as histology, fMRI, structural MRI and EEG.

Jordan DeKraker
Donna Gift Cabalo
Boris C. Bernhardt
ResearchOpen Access01 Oct 2025
Nature Methods

Volume: 22, P: 2211-2222
The Legend of Alexander and His Flying Machine

G. GREENHILL
News01 Mar 1918
Nature

Volume: 101, P: 25-26
The Naturalism of Samuel Alexander

F. I. G. RAWLINS
Books & Arts06 Aug 1949
Nature

Volume: 164, P: 204
Spin Hall and Edelstein effects in chiral non-collinear altermagnets

Recent work has expanded the concept of altermagnets to non-collinear magnetic materials. Here, Hu et al extend this further to non-collinear chiral materials, determining altermagnetic multipolar order parameters and predicting that such materials host large spin-hall and Edelstein effects.

Mengli Hu
Oleg Janson
Maia G. Vergniory
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-8
Higher mortality following SARS-CoV-2 infection in rural versus urban dwellers persists for two years post-infection

People living in rural areas of the United States have poorer outcomes from acute COVID-19. Here, the authors show that higher mortality rates among rural dwellers persist for up to two years after the initial infection, even after accounting for baseline risk factors.

A. Jerrod Anzalone
Michael T. Vest
Christopher G. Chute
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Neoadjuvant PD-1 and LAG-3-targeting bispecific antibody and other immune checkpoint inhibitor combinations in resectable melanoma: the randomized phase 1b/2 Morpheus-Melanoma trial

In the randomized phase 1b/2 Morpheus-Melanoma trial evaluating various neoadjuvant immune checkpoint inhibitor regimens in patients with resectable stage III melanoma, tobemstomig, an anti-PD-1/anti-LAG-3 bispecific antibody, showed the highest pathologic response rate with a better safety profile than the standard treatment approach of ipilimumab plus nivolumab.

Georgina V. Long
Nitya Nair
Christian Blank
ResearchOpen Access24 Sept 2025
Nature Medicine

P: 1-13
Natural speech reveals the semantic maps that tile human cerebral cortex

It has been proposed that language meaning is represented throughout the cerebral cortex in a distributed ‘semantic system’, but little is known about the details of this network; here, voxel-wise modelling of functional MRI data collected while subjects listened to natural stories is used to create a detailed atlas that maps representations of word meaning in the human brain.

Alexander G. Huth
Wendy A. de Heer
Jack L. Gallant
Research27 Apr 2016
Nature

Volume: 532, P: 453-458
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Research17 Sept 2025
Nature Genetics

Volume: 57, P: 2427-2435
60 cm² perovskite-silicon tandem solar cells with an efficiency of 28.9% by homogeneous passivation

The performance of inverted perovskite solar cells has been limited by non-radiative recombination at the perovskite surfaces. Here, authors employ phosphonic acids and piperazinium chloride for homogeneous passivation, achieving certified efficiency of 28.9% for 60 cm² perovskite-silicon tandems.

Kerem Artuk
Aleksandra Oranskaia
Christian M. Wolff
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-13
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis

This study explores the relationship between telomere length and clonal hematopoiesis. Splicing factor and PPM1D gene mutations are more frequent in people with genetically predicted shorter telomere lengths, suggesting that these mutations protect against the consequences of telomere attrition.

Matthew A. McLoughlin
Sruthi Cheloor Kovilakam
George S. Vassiliou
ResearchOpen Access28 Aug 2025
Nature Genetics

Volume: 57, P: 2215-2225
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Evaluation by Radioimmunoassay of Factors Controlling the Secretion of Parathyroid Hormone: Intravenous Infusions of Calcium and Ethylenediamine Tetraacetic Acid in the Cow and Goat

LOUIS M. SHERWOOD
JOHN T. POTTS JUN.
G. D. AURBACH
Research01 Jan 1966
Nature

Volume: 209, P: 52-55
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Ultraconfined terahertz phonon polaritons in hafnium dichalcogenides

The authors demonstrate deeply subwavelength light confinement in the terahertz spectral range by exploiting the strong light–matter coupling and hyperbolicity of phonon polaritons in hafnium-based dichalcogenides.

Ryan A. Kowalski
Niclas S. Mueller
Joshua D. Caldwell
ResearchOpen Access15 Sept 2025
Nature Materials

P: 1-7
Comparative genomics of Alexander Fleming’s original Penicillium isolate (IMI 15378) reveals sequence divergence of penicillin synthesis genes

Ayush Pathak
Reuben W. Nowell
Timothy G. Barraclough
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-10
Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
ALEXANDER GRAHAM BELL AND THE INVENTION OF THE TELEPHONE*

G. W. O. HOWE
News05 Apr 1947
Nature

Volume: 159, P: 455-457
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

Xueyi Shen
Miruna Barbu
Andrew M. McIntosh
ResearchOpen Access16 Sept 2025
Nature Mental Health

Volume: 3, P: 1152-1167
Effect of Nucleic Acids from Immune Lymphocytes on Rat Sarcomata

P. ALEXANDER
E. J. DELORME
J. G. HALL
Research01 Feb 1967
Nature

Volume: 213, P: 569-572
Mechanisms of Sensitization to X-Rays of Mammalian Cells by 5-Bromodeoxyuridine

J. T. LETT
G. PARKINS
M. G. ORMEROD
Research08 Aug 1964
Nature

Volume: 203, P: 593-596
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Disorganization of the Secondary Structure in Proteins Exposed to Ionizing Radiations in the Solid State

PETER ALEXANDER
L. D. G. HAMILTON
K. A. STACEY
Research25 Jul 1959
Nature

Volume: 184, P: 226-228
Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Shilpa Singh
Catherine E. Gleason
Matthew G. Oser
ResearchOpen Access20 Aug 2025
Nature

P: 1-12
Functional synapses between neurons and small cell lung cancer

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

Vignesh Sakthivelu
Anna Schmitt
Filippo Beleggia
ResearchOpen Access10 Sept 2025
Nature

P: 1-11

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