Nature Search

Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling

Exercise promotes recovery after stroke, but the underlying mechanisms are unclear. Here, the authors show that regulatory T cells enable exercise-induced repair by reducing neuronal hyperexcitability via interleukin-10, linking immunity to functional regeneration.

A. Schmidt-Pogoda
T. Ruck
J. Minnerup
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Stability of the marine nitrogen cycle over the past 165 million years

A 165 Myr record of N and Corg isotopes show that the N-cycle responds to feedbacks associated with productivity and the location of upwelling centers changing due to continental meander.

Linda V. Godfrey
Anne Willem Omta
Paul G. Falkowski
ResearchOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-13
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

C. Kleuss
J. Hescheler
B. Wittig
Research05 Sept 1991
Nature

Volume: 353, P: 43-48
Ultra-Violet Injury as an Experimental Model of The inflammatory Reaction

G. LOGAN
D. L. WILHELM
Research08 Jun 1963
Nature

Volume: 198, P: 968-969
Superoxide involvement in negative air ion effects (reply)

E. W. KELLOGG III
M. G. YOST
A. P. KRUEGER
Research18 Dec 1980
Nature

Volume: 288, P: 739-740
Inhibition of mammalian cytotoxic cells by phosphatidylcholine and its analogue

L. D. FRYE
G. J. FRIOU
Research27 Nov 1975
Nature

Volume: 258, P: 333-335
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
An inference approach for assessing place-based vulnerability to heat mortality

Junkang Xu
Chao Fan
Haoying Han
ResearchOpen Access14 Aug 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
VITAMINS OF THE B-GROUP REQUIRED BY INSECTS

G. FRAENKEL
M. BLEWETT
Research19 Jun 1943
Nature

Volume: 151, P: 703-704
Decrease in Upper-Atmosphere Density Since the Sunspot Maximum of 1957–58

D. G. KING-HELE
Research01 Jun 1963
Nature

Volume: 198, P: 832-834
Deposition of Strontium and Calcium in Snail Shell

G. M. ROSENTHAL Jun.
D. J. NELSON
D. A. GARDINER
Research03 Jul 1965
Nature

Volume: 207, P: 51-54
Epidermal Langerhans cells bear Fc and C3 receptors

G. STINGL
E. C. WOLFF-SCHREINER
K. WOLFF
Research21 Jul 1977
Nature

Volume: 268, P: 245-246
Nucleotide sequence of the origin of replication in bacteriophage ΦX174 RF DNA

S. A. Langeveld
A. D. M. van Mansfeld
P. J. Weisbeek
Research02 Feb 1978
Nature

Volume: 271, P: 417-420
Ice sheet topography by satellite altimetry

R. L. Brooks
W. J. Campbell
H. Jay Zwally
Research10 Aug 1978
Nature

Volume: 274, P: 539-543
Advancing biological understanding of cellular senescence with computational multiomics

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.

Sheng Li
Paula A. Agudelo Garcia
Rong Fan
Reviews15 Sept 2025
Nature Genetics

Volume: 57, P: 2381-2394
Hidden impacts of ocean warming and acidification on biological responses of marine animals revealed through meta-analysis

Climate change effects on animals are typically measured as decreases or increases in performance, compared to controls. Because both directions can have cascading effects at the ecosystem level, this study conducts a meta-analysis testing for deviations in biological responses using absolute rather than relative changes, showing that impacts on marine animals might have been largely underestimated.

Katharina Alter
Juliette Jacquemont
Paolo Domenici
ResearchOpen Access03 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Ia antigen expression on human epidermal Langerhans cells

G. ROWDEN
M. G. LEWIS
A. K. SULLIVAN
Research21 Jul 1977
Nature

Volume: 268, P: 247-248
Three-dimensional structure of yeast phenylalanine transfer RNA at 3. 0Å resolution

F. L. Suddath
G. J. Quigley
Alexander Rich
Research01 Mar 1974
Nature

Volume: 248, P: 20-24
Mild functional effects of a novel GFAP mutant allele identified in a familial case of adult-onset Alexander disease

Tiziana Bachetti
Francesco Caroli
Isabella Ceccherini
Research16 Jan 2008
European Journal of Human Genetics

Volume: 16, P: 462-470
Effect of Aerobic Pre-incubation on Glycolysis in Resting and Proliferating Liver Cells

G. GAJA
G. RAGNOTTI
A. BERNELLI-ZAZZERA
Research01 Jul 1965
Nature

Volume: 207, P: 538-539
Induction of Tumour Immunity with Tumour Cells Treated with Iodoacetate

CHARLES A. APFFEL
BARRY G. ARNASON
JOHN H. PETERS
Research12 Feb 1966
Nature

Volume: 209, P: 694-696
Cellular Basis of the Immunological Defects in Thymectomized Mice

J. F. A. P. MILLER
G. F. MITCHELL
N. S. WEISS
Research01 Jun 1967
Nature

Volume: 214, P: 992-997
In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque

In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.

Tina Drobnič
Eli J. Cohen
Morgan Beeby
ResearchOpen Access01 Jul 2025
Nature Microbiology

Volume: 10, P: 1723-1740
Initiation of Anaerobic Metabolism of Mammalian Spermatozoa by Carbon Dioxide

J. R. LODGE
G. W. SALISBURY
Research21 Jul 1962
Nature

Volume: 195, P: 293-294
A Multicenter Study of the Light Visor for Seasonal Affective Disorder: No Difference in Efficacy Found Between Two Different Intensities

Norman E. Rosenthal
Douglas E. Moul
Thomas A. Wehr
Research01 Feb 1993
Neuropsychopharmacology

Volume: 8, P: 151-160
Crystals of Fragment Fab′: Preparation from Pepsin Digests of Human IgG Myeloma Proteins

G. ROSSI
T. K. CHOI
A. NISONOFF
Research23 Aug 1969
Nature

Volume: 223, P: 837-838
Anaerobic Activation of Glycolysis in Tumour Tissue

F. DICKENS
G. D. GREVILLE
Research06 Aug 1932
Nature

Volume: 130, P: 206
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans

The underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a second brain event after seizure—spreading depolarization—a previously hidden phenomenon that may help to understand and optimize this treatment.

Zachary P. Rosenthal
Joseph B. Majeski
Ethan M. Goldberg
ResearchOpen Access18 May 2025
Nature Communications

Volume: 16, P: 1-14
CS and its Chemical Relatives

G. R. N. JONES
Research04 Feb 1972
Nature

Volume: 235, P: 257-261
Formation of Carotene in vitro

H. YOKOYAMA
C. O. CHICHESTER
G. MACKINNEY
Research05 Mar 1960
Nature

Volume: 185, P: 687-688
Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus

Lily J. Pearson
Jeremy L. Pinyon
Gary D. Housley
ResearchOpen Access25 Mar 2025
Scientific Reports

Volume: 15, P: 1-20
Reversible activation of non-steroid binding oestrogen receptor

William J. Raymoure
Reid W. McNaught
Roy G. Smith
Research25 Apr 1985
Nature

Volume: 314, P: 745-747
Spatial multiomic landscape of the human placenta at molecular resolution

The spatial single-cell multiomic atlas of the first trimester human placenta at molecular resolution provides a blueprint for future studies on early placental development and pregnancy.

Johain R. Ounadjela
Ke Zhang
Jian Shu
Research20 Nov 2024
Nature Medicine

Volume: 30, P: 3495-3508
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Identifying the molecular mechanisms of response to systemic therapy in prostate cancer remains crucial. Here, the authors apply single cell-ATAC and RNAseq to models of early treatment response and resistance to enzalutamide and identify chromatin and gene expression patterns that can predict treatment response.

S. Taavitsainen
N. Engedal
A. Urbanucci
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus

Walter Rosenthal
Anita Seibold
Daniel G. Bichet
Research17 Sept 1992
Nature

Volume: 359, P: 233-235
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Here the authors provide a single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis (MS) patients, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.

David Schafflick
Chenling A. Xu
Gerd Meyer zu Horste
ResearchOpen Access14 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Plasma Minerals in Normal and Neutron Irradiated Burros

THOMAS J. HALEY
FRANK D. CARTWRIGHT
DANIEL G. BROWN
Research19 Nov 1966
Nature

Volume: 212, P: 820-821
A well-oxygenated eastern tropical Pacific during the warm Miocene

Analysis of palaeoceanographic proxies sensitive to oxygen-deficient zone extent and intensity show that the eastern tropical Pacific was well oxygenated during the warm Miocene, agreeing with model simulations that suggest that the recent deoxygenation trend may eventually reverse.

Anya V. Hess
Alexandra Auderset
Alfredo Martínez-García
Research28 Jun 2023
Nature

Volume: 619, P: 521-525
Stepwise transition from the Eocene greenhouse to the Oligocene icehouse

The Eocene–Oligocene transition is the largest global cooling in the Cenozoic period. A comparison of three independent proxies from the continental shelf and deep ocean reveals a three-step transition to cold glacial conditions, with ice sheets 25% larger than their present size.

Miriam E. Katz
Kenneth G. Miller
Yair Rosenthal
Research13 Apr 2008
Nature Geoscience

Volume: 1, P: 329-334
A meta-analysis on global change drivers and the risk of infectious disease

Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.

Michael B. Mahon
Alexandra Sack
Jason R. Rohr
Research08 May 2024
Nature

Volume: 629, P: 830-836
Phosphatidylinositol is the membrane-anchoring domain of the Thy-1 glycoprotein

Martin G. Low
Paul W. Kincade
Research01 Nov 1985
Nature

Volume: 318, P: 62-64
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design

Discovery of new therapeutics has been hampered by the often-limiting resolution and throughput of cryo-EM. Here, the authors determine high-resolution cryo-EM structures of the CDK-activating kinase to establish a methodological framework for the use of cryo-EM in structure-based drug design.

Victoria I. Cushing
Adrian F. Koh
Basil J. Greber
ResearchOpen Access13 Mar 2024
Nature Communications

Volume: 15, P: 1-17
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to human and pangolin ACE2; although neither spike binds bat ACE2.

Antoni G. Wrobel
Donald J. Benton
Steven J. Gamblin
ResearchOpen Access05 Feb 2021
Nature Communications

Volume: 12, P: 1-6
Evolution of the mammalian G protein α subunit multigene family

Thomas M. Wilkie
Debra J. Gilbert
Neal G. Copeland
Research01 May 1992
Nature Genetics

Volume: 1, P: 85-91
Evolution of the SARS-CoV-2 spike protein in the human host

The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding.

Antoni G. Wrobel
Donald J. Benton
Steven J. Gamblin
ResearchOpen Access04 Mar 2022
Nature Communications

Volume: 13, P: 1-7
Floral changes across the Triassic/Jurassic boundary linked to flood basalt volcanism

The extinction at the Triassic/Jurassic boundary is one of the five largest in Earth’s history. Microfossil and organic geochemical analyses link the vegetation turnover in Europe to the release of pollutants and toxic compounds from flood basalt volcanism in the central Atlantic Ocean.

B. van de Schootbrugge
T. M. Quan
P. G. Falkowski
Research13 Jul 2009
Nature Geoscience

Volume: 2, P: 589-594
Discovery of intergalactic radio emission in the Coma–A1367 supercluster

K.-T. Kim
P. P. Kronberg
T. Venturi
Research26 Oct 1989
Nature

Volume: 341, P: 720-723

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