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Showing 1–7 of 7 results
Advanced filters: Author: Gad Asher Clear advanced filters

  • Little is known regarding the specificity and functional organization of peripheral clocks in mammals. Manella et al. find that the liver-clock is responsible for buffering the effects of nutrient challenges on the rhythmicity of other peripheral tissues.

    • Gal Manella
    • Elizabeth Sabath
    • Gad Asher
    Research
    Nature Metabolism
    Volume: 3, P: 829-842

  • Phase Transition Curves (PTCs) describe phase shifts of circadian oscillations due to a stimulus and they are important for studying circadian clock resetting. Here, the authors present a method for high-throughput reconstruction of PTCs using fluorescent live imaging and single-cell analysis.

    • Gal Manella
    • Dan Aizik
    • Gad Asher
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Patients with BRAFV600E-mutated colorectal cancer have encouraging overall response rates to inhibition of PD-1, BRAF and MEK, with translational analyses suggesting that induction of tumor-intrinsic programs and immune programs contributes to improved outcomes via MAPK inhibition.

    • Jun Tian
    • Jonathan H. Chen
    • Ryan B. Corcoran
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 458-466

  • This Review discusses the role of the circadian clock in liver homeostasis, and how dysfunction of the liver circadian clock is associated with several liver-related diseases, including nonalcoholic fatty liver disease, type 2 diabetes mellitus and hepatocellular carcinoma.

    • Nityanand Bolshette
    • Hussam Ibrahim
    • Gad Asher
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 20, P: 695-707

  • Circadian rhythms align organismal functions with phases of rest and activity. Accordingly, circadian oscillations occur in many physiological processes, including various metabolic functions. In turn, metabolic cues are emerging as regulators of the circadian clock. This crosstalk between metabolism and circadian rhythms has important implications for human health.

    • Hans Reinke
    • Gad Asher
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 227-241