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ERDRP-0519 is a potent nonnucleoside inhibitor of Morbilliviruses. In this work, authors solve cryo-EM structures that reveal ERDRP-0519 bound to measles RNA polymerase in a unique RdRp palm pocket, clarifying resistance mutations and guiding next-generation antivirals.

In drug discovery, the preparation of analogues with diverse core structures often requires laborious efforts. Now it has been shown that 1,2-oxaborines, which are synthesized from readily available starting materials, can serve as a versatile platform to allow rapid access to diverse central skeletons, thus simplifying the core diversification process.

Whole-exome sequencing analyses in a cohort of 2,140 participants with female infertility after recurrent in vitro fertilization, coupled with functional analyses, identified genes associated with oocyte and early embryo competence defects.

Mycobacterium tuberculosis produces linoleic acid, which is released from macrophages during infection and upregulates regulatory T cell activity, to suppress macrophage control of intracellular bacteria in mice.

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.

Here the authors show a role for long-distance ROS signaling in driving the recruitment and colonization of beneficial rhizobacteria by plants. This allows plants to establish acclimation in systemic tissues following local organic pollutant stress.

The authors show that the endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate cholesterol biosynthesis, sequestering SCAP when endoplasmic reticulum cholesterol is high but dissociating upon low cholesterol levels, allowing SCAP to activate cholesterol synthesis.

Metal–support interfaces play a crucial role in dictating the catalytic behavior of heterogeneous systems. Here, the authors reveal a unique looping metal–support interaction in NiFe–Fe₃O₄ catalysts, where spatially separated yet coupled redox cycles boost hydrogen oxidation, providing new insights for the design of efficient heterogeneous catalysts.

Achieving room-temperature blackbody-sensitive photodetectors with an ultrabroadband response is challenging. Here, the authors report a bioinspired detector using the 2D flat-band quantum material Nb3I8 that enables sensitive detection from the shortwave to the very long-wave infrared.

A comprehensive phylogeny and taxonomy for the medically and ecologically important genus Artemisia remain unavailable. Here, the authors combine genomic data with morphological analyses to reconstruct the most comprehensive phylogeny and taxonomy of global Artemisia.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The authors obtain tetragonal La3Ni2O6.92 single crystals at ambient pressure by post-annealing in a high-oxygen-pressure environment. Experimental results on these samples suggest that the tetragonal structure is not a prerequisite for achieving superconductivity in La3Ni2O7.

How replication stress affects nuclear integrity is not fully understood. Here, the authors report that replication stress induces DNA damage and nuclear envelope reassembly defect during mitosis, which is suppressed by DNA polymerase theta mediated end joining.

Delamination and cracking hinder the durability of air electrodes in ceramic cells. Here, the authors introduce oxide wedging at particle interfaces to enhance mechanical robustness and thermal compatibility, significantly improving electrode longevity.

Anode catalysts in proton-exchange-membrane water electrolyzers usually trade activity for stability. Here, the authors report an electronic-structure-tuning strategy that modulates the metal–oxygen redox behavior of RuO₂, yielding a catalyst that is both highly active and durable.

Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

The hydrovoltaic effect offers a promising route for ion sensing but is limited by a long response time. Here, the authors leverage rapid ion transport within nanochannels to achieve a high voltage output of 4.0 V with a response time of just 0.17 s.

The authors present evidence based on satellite observations that the local cooling effect of potential forestation in Europe has intensified over the past two decades, driven by the reduced winter snow cover and declining summer soil moisture under global warming.

Influenza A virus neuraminidase (NA) is an important target for universal influenza vaccines. Here, the authors identify two monoclonal antibodies, CAV-F6 and CAV-F34, that inhibit NA activity across multiple subtypes, offering protection against seasonal and emerging avian influenza strains, thus advancing the development of broadly protective vaccines and therapeutics.

Using two cohorts, Liu, Ge, Xiao, Lu and colleagues perform plasma metabolomics and lipidomics, linking reduced sarcosine to sarcopenia diagnosis. In mice, they demonstrate that sarcosine enhances muscle repair, boosts adipose thermogenesis and preserves muscle mass via macrophage modulation.

Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.

The conventional focus on pore size distribution overlooks the role of surface charge homogeneity in ion separation by polymeric membranes. This study proposes a surface charge engineering strategy for fabricating highly ion-selective membranes.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The authors find the hidden out-of-plane antiferroelectricity and field-induced ferroelectric polarization in spatial-inversion symmetric GeSe, which may be extended to other centrosymmetric van der Waals layered materials.

Some small mRNA isoforms regulate cellular responses to stress. Here, Li et al. identify UFD1s, a stress responsive micro-RNA that encodes a conserved microprotein that regulates ubiquitination of full length UFD1, promotes autophagy and fatty acid oxidation, and acts to alleviate NASH progression in mice.

Polyploidy and subsequent post-polyploid diploidization (PPD) contribute to evolutionary success of plant species. Here, using 11 genomes from all nine subfamilies of Malvaceae as an example, the authors provide evidence to support the “polyploidy for survival and PPD for success” hypothesis.

Thinopyrum intermedium and Roegneria kamoji are wheat relatives commonly used in distant hybridization breeding program. Here, the authors report the genome assemblies of the two species and reveal their phylogenetic relationship and genome compositions.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

In the dose-expansion cohort of this phase 1b trial, the EGFR×HER3 bispecific antibody–drug conjugate BL-B01D1 given to patients with metastatic esophageal squamous cell carcinoma led to encouraging clinical response rates, which need to be confirmed in larger efficacy trials.

Desmocollin 2 (DSC2) binds to the EBV glycoprotein H/glycoprotein L complex and allows for virus entry to epithelial cells, which could be blocked by DSC2-specific antibodies. DSC2 allowed for virus entry independent of Ephrin receptor A2.

Here the authors uncover how a floppy tail in a protein acts as a remote switch, flipping activity on or off by tweaking internal motion, which reveals a powerful new way proteins regulate themselves without direct contact.

In the multicenter phase 2 OptiTROP-Lung01 trial in patients with treatment-naive advanced non-small-cell lung cancers, the antibody–drug conjugate sacituzumab tirumotecan with anti-PD-L1 tagitanlimab was safe and showed encouraging clinical efficacy.

La₅Ni₃O₁₁, a hybrid Ruddlesden–Popper nickelate, exhibits pressure-induced superconductivity with a high superconducting volume fraction. It offers insights into the interplay of structure and electronic order in nickelate superconductors.

The efficiency of narrow bandgap subcells is hindered by structural instability and strain accumulation. The authors introduce a rigid sulfonate molecule that suppresses light-induced lattice distortions, enabling certified 29.2% efficiency in all-perovskite tandem solar cells.

In this work, authors show that Mycobacterium bovis exploits frd operon phase variation to hijack host immunity. By disrupting bacterial succinate production, identified mutations steer immunity toward harmful Th17 responses instead of protective Th1, worsening disease.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The mechanisms underlying circadian homeostasis remain elusive. Here, the authors show that anti-Müllerian hormone (Amh)-mediated signaling sustains molecular clock oscillations in the pituitary gland, thereby maintaining circadian homeostasis at both tissue and systemic levels.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

Early human embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here the authors present LiCAT-seq, a method enabling simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells and map chromatin accessibility and transcriptome landscapes for human pre-implantation embryos.

Methane can be converted into other useful chemicals and fuels via photocatalytic oxidative coupling, yet producing molecules with more than two carbon atoms remains difficult. Here the authors show that highly strained Au confined within the nanopores of TiO₂ can convert methane to propane with high selectivity.

The authors demonstrate enhanced energy storage performance and thermal stability in lead-free Bi_0.5Na_0.5TiO₃-based multilayer capacitors by employing a hierarchical design strategy across composition, microstructure, and device architecture.

This study identifies monoclonal antibodies A138 and B026 targeting MPXV proteins M1R and B6R. Both antibodies exhibit neutralization of MPXV and VACV, and their combination enhances protective efficacy in mice, supporting a dual-targeting strategy.

Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.