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Showing 1–4 of 4 results

Advanced filters: Author: Geoffrey D. Girnun Clear advanced filters

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

In ischaemic tissues, hypoxia and nutrient deprivation were found to induce the transcriptional regulator PGC-1α which in turn induces VEGF to promote angiogenesis; this pathway is independent of hypoxia-inducible factor, which is also implicated in hypoxia-induced VEGF regulation and angiogenesis.

Zoltan Arany
Shi-Yin Foo
Bruce M. Spiegelman
Research21 Feb 2008
Nature

Volume: 451, P: 1008-1012
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

Cancer cells develop specific metabolic adaptations. Here, the authors show that in prostate cancer models, the ubiquitin ligase Hect9 promotes tumor growth by accelerating glucose metabolism via ubiquitination of Hexokinase 2, a central regulator of glycolysis.

Hong-Jen Lee
Chien-Feng Li
Chia-Hsin Chan
ResearchOpen Access14 Jun 2019
Nature Communications

Volume: 10, P: 1-16
Author Correction: Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice

Hermes Reyes-caballero
Xiaoquan Rao
Shyam Biswal
Amendments and CorrectionsOpen Access16 Mar 2020
Scientific Reports

Volume: 10, P: 1
Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice

Hermes Reyes-Caballero
Xiaoquan Rao
Shyam Biswal
ResearchOpen Access22 Nov 2019
Scientific Reports

Volume: 9, P: 1-10