Nature Search

On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging

Tryptophan metabolism through the kynurenine pathway changes with age and represents a potential intervention target for age associated disease. Here, the authors show that elevating physiological levels of the kynurenine pathway metabolite 3- hydroxyanthranilic acid can promote healthy aging.

Hope Dang
Raul Castro-Portuguez
George L. Sutphin
ResearchOpen Access14 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Isolated flagellar outer arm dynein translocates brain microtubules in vitro

Bryce M. Paschal
Stephen M. King
George B. Witman
Research23 Dec 1987
Nature

Volume: 330, P: 672-674
Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor

Thomas J. Girard
Louise A. Warren
George J. Broze Jr
Research06 Apr 1989
Nature

Volume: 338, P: 518-520
The impact of chemical reactivity on the quality and stability of RNA–LNP pharmaceuticals

Lipid nanoparticle-based delivery vehicles for mRNA are assembled from several different components. This Perspective discusses how these components react with each other and pose a particular analytical challenge that must be addressed to ensure the reproducibility, stability and safety of such drug formulations.

Tristan Kovačič
Heinrich Haas
Dan Peer
Reviews08 Oct 2025
Nature Reviews Chemistry

Volume: 9, P: 790-802
Activin A more prominently regulates muscle mass in primates than does GDF8

Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.

Esther Latres
Jason Mastaitis
Jesper Gromada
ResearchOpen Access28 Apr 2017
Nature Communications

Volume: 8, P: 1-13
ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts

Osteoclastic bone destruction is mediated by factors such as RANKL elaborated by tissue-destructive fibroblasts. Takayanagi and colleagues identify the transcription factor Ets1 as a major regulator of these pathogenic cells.

Minglu Yan
Noriko Komatsu
Hiroshi Takayanagi
Research23 Aug 2022
Nature Immunology

Volume: 23, P: 1330-1341
Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

Melissa L Perreault
Ahmed Hasbi
Susan R George
Reviews18 Jun 2013
Neuropsychopharmacology

Volume: 39, P: 156-168
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

Bar-Eli and colleagues report that CREB-mediated downregulation of the RNA-editing enzyme ADAR1 results in decreased adenosine-to-inosine editing of miR-455-5p, which enhances melanoma growth and metastasis.

Einav Shoshan
Aaron K. Mobley
Menashe Bar-Eli
Research16 Feb 2015
Nature Cell Biology

Volume: 17, P: 311-321
Dimerization and Domain Swapping in G-Protein-Coupled Receptors: A Computational Study

Paul R Gouldson
Christopher Higgs
Christopher A Reynolds
Research01 Oct 2000
Neuropsychopharmacology

Volume: 23, P: S60-S77
Alpha activity neuromodulation induced by individual alpha-based neurofeedback learning in ecological context: a double-blind randomized study

Fanny Grosselin
Audrey Breton
Nathalie George
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-15
LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins

Liora Lindenboim
Hila Zohar
Reuven Stein
ResearchOpen Access15 Jan 2024
Cell Death Discovery

Volume: 10, P: 1-12
Aligning artificial intelligence with climate change mitigation

The rapid growth of artificial intelligence (AI) is reshaping our society in many ways, and climate change is no exception. This Perspective presents a framework to assess how AI affects GHG emissions and proposes approaches to align the technology with climate change mitigation.

Lynn H. Kaack
Priya L. Donti
David Rolnick
Reviews09 Jun 2022
Nature Climate Change

Volume: 12, P: 518-527
Multi-attenuated herpes simplex virus-1 mutant G207 exerts cytotoxicity against epithelial ovarian cancer but not normal mesothelium and is suitable for intraperitoneal oncolytic therapy

George Coukos
Antonis Makrigiannakis
Katherine L Molnar-Kimber
Research24 May 2000
Cancer Gene Therapy

Volume: 7, P: 275-283
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
ResearchOpen Access16 Aug 2021
Scientific Data

Volume: 8, P: 1-17
Generic acquisition protocol for quantitative MRI of the spinal cord

A protocol for quantitative MRI of the spinal cord using 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The authors offer guidance for assessing macrostructural and microstructural integrity using various imaging approaches.

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
Protocols16 Aug 2021
Nature Protocols

Volume: 16, P: 4611-4632
Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
Amendments and CorrectionsOpen Access23 Sept 2021
Scientific Data

Volume: 8, P: 1-2
Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Julien Cohen-Adad
Eva Alonso-Ortiz
Junqian Xu
Amendments and CorrectionsOpen Access10 Sept 2021
Scientific Data

Volume: 8, P: 1

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On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging

Isolated flagellar outer arm dynein translocates brain microtubules in vitro

Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor

The impact of chemical reactivity on the quality and stability of RNA–LNP pharmaceuticals

Activin A more prominently regulates muscle mass in primates than does GDF8

ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

Dimerization and Domain Swapping in G-Protein-Coupled Receptors: A Computational Study

Alpha activity neuromodulation induced by individual alpha-based neurofeedback learning in ecological context: a double-blind randomized study

LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins

Aligning artificial intelligence with climate change mitigation

Multi-attenuated herpes simplex virus-1 mutant G207 exerts cytotoxicity against epithelial ovarian cancer but not normal mesothelium and is suitable for intraperitoneal oncolytic therapy

Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Generic acquisition protocol for quantitative MRI of the spinal cord

Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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