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Showing 1–6 of 6 results
Advanced filters: Author: George Pyrowolakis Clear advanced filters

  • Dpp, a member of the TGF-β signaling family, is a key regulator during Drosophila development. An activation element upstream of the dad gene is now shown to operate by integrating repressive and activating inputs and allows the identification of other Dpp target genes.

    • Alexander Weiss
    • Enrica Charbonnier
    • Markus Affolter
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 69-76

  • Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization into endocytic vesicles.

    • Xiaoyu Tracy Cai
    • Hongjie Li
    • Heinrich Jasper
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Morphogens direct cell fates across tissues through concentration gradients. Pentagone, a secreted protein and a newly identified target of the Drosophila bone morphogenetic protein decapentaplegic (Dpp), is shown to promote long-range distribution of the Dpp ligand in the wing through its binding to the heparan-sulphate proteoglycan Dally.

    • Robin Vuilleumier
    • Alexander Springhorn
    • George Pyrowolakis
    Research
    Nature Cell Biology
    Volume: 12, P: 611-617

  • A new study has revealed an unexpected role for eukaryotic translation initiation factor 4A (eIF4A) in suppressing Decapentaplegic (Dpp) signalling. On activation of Dpp signalling, eIF4A promotes degradation of the downstream signalling components Mad and Medea in a translation-independent manner.

    • Markus Affolter
    • George Pyrowolakis
    News & Views
    Nature Cell Biology
    Volume: 8, P: 1319-1321