Nature Search

Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy

Cisca Wijmenga
Jane E. Hewitt
Rune R. Frants
Research01 Sept 1992
Nature Genetics

Volume: 2, P: 26-30
Trust in scientists and their role in society across 68 countries

What is the state of trust in scientists around the world? To answer this question, the authors surveyed 71,922 respondents in 68 countries and found that trust in scientists is moderately high.

Viktoria Cologna
Niels G. Mede
Rolf A. Zwaan
ResearchOpen Access20 Jan 2025
Nature Human Behaviour

Volume: 9, P: 713-730
BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

Anne Petrij-Bosch
Tamara Peelen
Peter Devilee
Research01 Nov 1997
Nature Genetics

Volume: 17, P: 341-345
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis

DYW domains catalyse cytidine deamination in plant RNA editing, but information on their structure and mode of action were lacking. Now, crystal structures of the DYW domain are reported and a gating domain, key catalytic residues and an unusual protein regulation mechanism are revealed.

Mizuki Takenaka
Sachi Takenaka
Gert Weber
ResearchOpen Access21 Jun 2021
Nature Catalysis

Volume: 4, P: 510-522
A New Case of Purine Nucleoside Phosphorylase Deficiency: Enzymologic, Clinical, and Immunologic Characteristics

Gert Rijksen
Wietse Kuis
Ben J M Zegers
Research01 Feb 1987
Pediatric Research

Volume: 21, P: 137-141
Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate

Plastic polymer PET degrading enzymes are of great interest for achieving sustainable plastics recycling. Here, the authors present the crystal structures of the plastic degrading bacterial enzymes PETase, MHETase in its apo-form and MHETase bound to a non-hydrolyzable substrate analog.

Gottfried J. Palm
Lukas Reisky
Gert Weber
ResearchOpen Access12 Apr 2019
Nature Communications

Volume: 10, P: 1-10
Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

eIF5A is the only protein known to contain hypusine. Here, the authors present the cryoEM structure of the eIF5A-DHS complex and provide mechanistic insights to understand the deoxyhypusination reaction and hypusination-related neurodegeneration.

Elżbieta Wątor
Piotr Wilk
Przemysław Grudnik
ResearchOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1-14
A growth selection system for the directed evolution of amine-forming or converting enzymes

Fast screening of enzymes is key for directed evolution of industrial biocatalysts. Here, the authors report a simple, high-throughput, and low-equipment-dependent growth selection system for engineering three enzymes for synthesis of chiral amines.

Shuke Wu
Chao Xiang
Uwe T. Bornscheuer
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-10
Standardization guidelines and future trends for PET hydrolase research

Enzymatic depolymerization of polyethylene terephthalate (PET) towards monomer recycling is a promising strategy for a bio-based circular plastic economy, but progress is limited by the lack of standard guidelines for assessing and comparing the depolymerization efficiency catalysed by various PET hydrolases. In this Perspective, the authors identify critical research gaps in sourcing novel PET hydrolases and specify crucial requirements for selecting and optimizing them for specific application scenarios.

Ren Wei
Peter Westh
Uwe T. Bornscheuer
ReviewsOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-13
A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

Bergfort et al. use biochemistry, cryoEM, structure-guided mutagenesis, transcriptomics and proteomics to reveal how the intrinsically unstructured C9ORF78 protein binds BRR2 and PRPF8, regulating cassette exons and alternative 3’-splice sites.

Alexandra Bergfort
Marco Preußner
Markus C. Wahl
ResearchOpen Access03 Mar 2022
Nature Communications

Volume: 13, P: 1-16
Structural basis for λN-dependent processive transcription antitermination

Structural characterization sheds mechanistic insights behind λN-dependent processive antitermination.

Nelly Said
Ferdinand Krupp
Markus C. Wahl
Research28 Apr 2017
Nature Microbiology

Volume: 2, P: 1-13
Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis

The function of many non-membrane bound aggregates (Cajal bodies, P-bodies, stress granules, etc.) is poorly understood. Now studies in zebrafish embryos show that coilin promotes spliceosomal small nuclear ribonucleoproteins (snRNPs) assembly, most likely by concentrating snRNP components in Cajal bodies and to overcome a rate-limiting step(s) in assembly.

Magdalena Strzelecka
Simon Trowitzsch
Karla M Neugebauer
Research28 Mar 2010
Nature Structural & Molecular Biology

Volume: 17, P: 403-409
A conserved influenza A virus nucleoprotein code controls specific viral genome packaging

The nucleotide sequence of the eight genomic RNA segments of influenza A virus provides essential packaging signals, but how these sequences are recognized is unknown. Here, Moreira et al. identify conserved amino acids in the viral nucleoprotein that regulate packaging of RNA segments.

Étori Aguiar Moreira
Anna Weber
Mindaugas Juozapaitis
ResearchOpen Access21 Sept 2016
Nature Communications

Volume: 7, P: 1-11
Are political representatives more risk-loving than the electorate? Evidence from German federal and state parliaments

Moritz Heß
Christian von Scheve
Gert G. Wagner
ResearchOpen Access29 May 2018
Palgrave Communications

Volume: 4, P: 1-7
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.

Gert Weber
Gregory T. DeKoster
Markus C. Wahl
ResearchOpen Access07 Jun 2018
Nature Communications

Volume: 9, P: 1-16
A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching

Brakemann et al. present a reversibly photoswitchable fluorescent protein, called Dreiklang, that can be turned on and off at wavelengths distinct from those used for imaging. They show that the protein is advantageous for studying protein dynamics in living cells and for super-resolution imaging.

Tanja Brakemann
Andre C Stiel
Stefan Jakobs
Research11 Sept 2011
Nature Biotechnology

Volume: 29, P: 942-947
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Process insights for harnessing biotechnology for plastic depolymerization

Plastics play an essential role in modern life, but their uncontrolled disposal has led to severe environmental impacts. Sustainable strategies for reusing plastics waste are urgently needed. This Perspective examines biotechnological solutions for plastics recycling and upcycling, with an emphasis on the process-oriented challenges involved in achieving a circular plastics economy.

Ren Wei
Gert Weber
Uwe T. Bornscheuer
Reviews17 Feb 2025
Nature Chemical Engineering

Volume: 2, P: 110-117
LY6E impairs coronavirus fusion and confers immune control of viral disease

Here, the authors identify lymphocyte antigen 6E (LY6E) as a coronavirus (CoV) restriction factor that prevents infection of B cells and dendritic cells. LY6E inhibits both human and mouse CoV entry into cells by interfering with viral spike protein-mediated membrane fusion. It facilitates an antiviral immune response that prevents liver disease and reduces death in the mouse model of MHV-A59 CoV infection.

Stephanie Pfaender
Katrina B. Mar
Volker Thiel
Research23 Jul 2020
Nature Microbiology

Volume: 5, P: 1330-1339
Plasticity in gustatory and nociceptive neurons controls decision making in C. elegans salt navigation

Martijn Dekkers and Felix Salfelder et al. combine experimental approaches and mathematical modeling to determine the contribution of the two main NaCl sensory neurons (termed ASEL and ASER) and the nociceptive neurons (termed ASH) in C. elegans to the context-dependent switching between NaCl attraction and avoidance. Their results show that regulated sensitivity of these sensory neurons to NaCl allows the animal to dynamically modulate its behavioral response and suggest a role for sensory modulation in balancing exploration and exploitation during foraging.

Martijn P. J. Dekkers
Felix Salfelder
Gert Jansen
ResearchOpen Access09 Sept 2021
Communications Biology

Volume: 4, P: 1-14
Further Localization of the Gene for Hereditary Paragangliomas and Evidence for Linkage in Unrelated Families

Peter Heutink
Evert M. van Schothorst
Peter Devilee
Research01 Jul 1994
European Journal of Human Genetics

Volume: 2, P: 148-158
How people know their risk preference

Ruben C. Arslan
Martin Brümmer
Gert G. Wagner
ResearchOpen Access21 Sept 2020
Scientific Reports

Volume: 10, P: 1-14
Helical extension of the neuronal SNARE complex into the membrane

In neurotransmission, synaptic vesicles fuse with the membrane of nerve cells to release neurotransmitter content into the synaptic cleft. This process requires the assembly of several members of the SNARE protein family. Here, the X-ray structure of a neuronal SNARE complex is solved, providing insight into how these proteins assemble.

Alexander Stein
Gert Weber
Reinhard Jahn
Research01 Jul 2009
Nature

Volume: 460, P: 525-528
Perceptions of science, science communication, and climate change attitudes in 68 countries – the TISP dataset

Niels G. Mede
Viktoria Cologna
Rolf A. Zwaan
ResearchOpen Access20 Jan 2025
Scientific Data

Volume: 12, P: 1-27
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Zuzana Kos
Elvire Roblin
Zsuzsanna Bago-Horvath
ResearchOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-16
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Mohamed Amgad
Elisabeth Specht Stovgaard
Zaheed Husain
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-13
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jan Hudeček
Leonie Voorwerk
Zsuzsanna Bago-Horvath
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-8

Search

Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy

Trust in scientists and their role in society across 68 countries

BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

Diminishing benefits of urban living for children and adolescents’ growth and development

DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis

A New Case of Purine Nucleoside Phosphorylase Deficiency: Enzymologic, Clinical, and Immunologic Characteristics

Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

A growth selection system for the directed evolution of amine-forming or converting enzymes

Standardization guidelines and future trends for PET hydrolase research

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing

Structural basis for λN-dependent processive transcription antitermination

Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis

A conserved influenza A virus nucleoprotein code controls specific viral genome packaging

Are political representatives more risk-loving than the electorate? Evidence from German federal and state parliaments

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Process insights for harnessing biotechnology for plastic depolymerization

LY6E impairs coronavirus fusion and confers immune control of viral disease

Plasticity in gustatory and nociceptive neurons controls decision making in C. elegans salt navigation

Further Localization of the Gene for Hereditary Paragangliomas and Evidence for Linkage in Unrelated Families

How people know their risk preference

Helical extension of the neuronal SNARE complex into the membrane

Perceptions of science, science communication, and climate change attitudes in 68 countries – the TISP dataset

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

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