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In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

Head and neck squamous cell carcinoma (HNSCC) frequency and risk factors vary considerably across regions and ancestries. Here, the authors conduct a multi-ancestry genome-wide association study and fine mapping study of HNSCC subsites in cohorts from multiple continents, finding susceptibility and protective loci, gene-environment interactions, and gene variants related to immune response.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Short laser pulses of femtosecond time scales are in high demand in order to explore the fast electron dynamics in light-matter interactions. Here, the authors demonstrated the compression of free electron laser pulses in the extreme ultraviolet range by using a chirped pulse amplification technique.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

The homeostasis and function of adipose tissue are tightly regulated by immune cells, with macrophages playing a pivotal role. Here the authors show that PpargHIGH macrophages positively enhance brown adipose tissue thermogenesis through GDF15.

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The Berezinskii–Kosterlitz–Thouless transition is observed in a 2D gas of exciton-polaritons, through measurements of the first-order coherence both in space and time.

Supramolecular gels whose properties can be tuned through non-covalent interactions — typically metal coordination or hydrogen bonding — are attracting attention in various fields. Researchers have now shown that halogen bonding is also strong enough to be relied on; it interferes with competitive, gel-inhibitory hydrogen bonding to induce co-gelation between two urea-based components.

Light-sensitive azobenzene compounds can be engineered to stably partition into the plasma membrane, thus causing its thinning in the dark and relaxation upon light stimulation. In neurons, the resulting light-dependent change in membrane capacitance induces a transient hyperpolarization followed by rebound depolarization and action potential firing.

Paper is a promising substrate for flexible and environmentally sustainable electronic devices. Here, the authors combine chemical vapor deposition of MoS₂ with inkjet printing of a hexagonal boron nitride (hBN) dielectric and silver electrodes, to fabricate flexible MoS₂ field-effect transistors on paper, and then combine the latter with printed graphene resistors and silver interconnects to create inverters, logic gates and current mirrors.

Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.

Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. Here, the authors show the ability of human embryonic stem cells (hESCs) to recapitulate the different TC histotypes upon specific genomic alterations delivered by CRISPR-Cas9 and identify KISS1R and TIMP1 targeting as a therapeutic adjuvant option for undifferentiated TCs.

The peripheral nervous system uses neuroimmune cardiovascular interfaces to assemble a structural artery–brain circuit, and therapeutic intervention in the artery–brain circuit attenuates atherosclerosis.

Many mountain species are threatened by climate change and habitat loss. Here, the authors investigate population declines and range shifts of orchids in an alpine region in NE Italy over 28 years. For most species, population size decreased, while range shifts were idiosyncratic with over half of the species lagging behind climate change.

Superfluidity is a phenomenon usually restricted to cryogenic temperatures, but organic microcavities provide the conditions for a superfluid flow of polaritons at room temperature.

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

The final state of self-assembled systems is determined by both their thermodynamic and kinetic pathways. Di Michele et al.develop a strategy to realize predesigned amorphous structures of complex DNA colloidal mixtures by selectively activating local inter- or intra-species interactions upon freezing.

A minimal observable length leading to deformed commutation relations is a common feature of theories that aim to merge quantum physics and gravity. Here, the authors analyse the free evolution of micro- and nano-oscillators to lower the limits on the parameters quantifying commutator deformation.

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.

Superfluid flow around a vortex is quantized so that vortices become discrete, particle-like defects, with interactions mediated by the surrounding fluid. Here, the authors use a polariton system to experimentally investigate the behavior and scattering of vortices in a two-component superfluid.

The signatures of water, carbon monoxide, hydrogen cyanide, methane, ammonia and acetylene are observed in the transmission spectrum of the hot Jupiter HD 209458b, with abundance ratios suggesting a super-solar carbon-to-oxygen ratio.

The exclusive expression of well-defined antigens renders prostate cancer an attractive target for immunotherapy. Di Lorenzoet al. review clinical results of immunotherapy trials in patients with prostate cancer and discuss methodological issues related to the evaluation of treatment efficacy of immunotherapeutic agents.

By amplifying a soliton in a multistage cascade, few-femtosecond extreme-ultraviolet free-electron laser pulses are achieved.

Two-colour X-ray free electron laser is a powerful tool for pump–probe measurements, but currently constrained by limited tunability. Here, Ferrari et al. develop a configuration that allows tuning both the pump and the probe to specific electronic excitations, providing element selectivity.

In a comprehensive dataset from 3,652 patients across 20 centers in eight countries, an ultrasound-based AI model shows robust performance across centers, ultrasound systems, 58 histological diagnoses and patient age groups and reduced referral to experts by 63% in a retrospective triage simulation.

Magnetic molecules have long been seen to hold promise in magnetic sensing applications. In this paper, Serrano et al show that a single layer of a magnetic molecule, a terbium based complex, is sensitive to the local magnetic field variation of a superconducting surface on which it is deposited.

Engineering the energy dispersion of polaritons in microcavities can yield intriguing effects such as the anomalous quantum Hall and Rashba effects. Now, different Berry curvature distributions of polariton bands are obtained in a strongly coupled organic–inorganic two-dimensional perovskite single-crystal microcavity and can be modified via temperature and magnetic field variation.

The measurement of molecular diffusion at sub-diffraction scales has been achieved in 2D space using STED-FCS, but an implementation for 3D diffusion is lacking. Here the authors present an analytical approach to probe diffusion in 3D space using STED-FCS and measure the diffusion of EGFP at different spatial scales.