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Paediatric renal tumours: perspectives from the SIOP–RTSG

Filippo Spreafico
Marry M. van den Heuvel-Eibrink
Norbert Graf
Comments & Opinion06 Dec 2016
Nature Reviews Urology

Volume: 14, P: 3-4
The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol

In this Consensus Statement, the pathology panel of the International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RSTG) present the pathology and molecular biology protocol for Wilms tumours in the UMBRELLA SIOP-RTSG 2016 protocol.

Gordan M. Vujanić
Manfred Gessler
Norbert Graf
ReviewsOpen Access11 Oct 2018
Nature Reviews Urology

Volume: 15, P: 693-701
High resolution clonal architecture of hypomutated Wilms tumours

It remains unclear why some paediatric tumours appear to have such a low mutation burden. Here, the authors shed light on this paradox by analysing Wilms tumours using high resolution and high depth sequencing approaches, finding that - due to an unusual clonal architecture - standard methods significantly underestimate the mutation burden at the cellular level.

Henry Lee-Six
Taryn D. Treger
Sam Behjati
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-10
Anaplastic sarcomas of the kidney are characterized by DICER1 mutations

Mona K Wu
Gordan M Vujanic
William D Foulkes
Research01 Sept 2017
Modern Pathology

Volume: 31, P: 169-178
Publisher Correction: The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol

Gordan M. Vujanić
Manfred Gessler
Norbert Graf
Amendments and Corrections01 May 2019
Nature Reviews Urology

Volume: 16, P: 563
Characteristics and outcome of synchronous bilateral Wilms tumour in the SIOP WT 2001 Study: Report from the SIOP Renal Tumour Study Group (SIOP-RTSG)

Hélène Sudour-Bonnange
Harm van Tinteren
Rhoikos Furtwängler
Research30 Jul 2024
British Journal of Cancer

Volume: 131, P: 972-981
Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol). In this Consensus Statement, members of SIOP–RTSG outline the rationale for the recommendations in the protocol.

Marry M. van den Heuvel-Eibrink
Janna A. Hol
Norbert Graf
ReviewsOpen Access31 Oct 2017
Nature Reviews Urology

Volume: 14, P: 743-752
Wilms tumour

Wilms tumour (WT) is the most common renal tumour in infants and young children. This Primer reviews the epidemiology, mechanisms, diagnosis and management of WT. In addition, the authors outline potential opportunities to translate novel biological targets to improve clinical outcomes.

Filippo Spreafico
Conrad V. Fernandez
Kathy Pritchard-Jones
Reviews14 Oct 2021
Nature Reviews Disease Primers

Volume: 7, P: 1-21
Rationale for the treatment of children with CCSK in the UMBRELLA SIOP–RTSG 2016 protocol

The International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol). In this Consensus Statement, members of the SIOP–RTSG outline the rationale for the recommendations for treatment of CCSK in the protocol.

Saskia L. Gooskens
Norbert Graf
Marry M. van den Heuvel-Eibrink
ReviewsOpen Access27 Feb 2018
Nature Reviews Urology

Volume: 15, P: 309-319
A tribute to Prof. Ondrej Hes, MD, PhD (1968–2022)

Reza Alaghehbandan
Abbas Agaimy
Michal Michal
Comments & Opinion04 Nov 2022
Modern Pathology

Volume: 35, P: 2023-2024

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Paediatric renal tumours: perspectives from the SIOP–RTSG

The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol

High resolution clonal architecture of hypomutated Wilms tumours

Anaplastic sarcomas of the kidney are characterized by DICER1 mutations

Publisher Correction: The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol

Characteristics and outcome of synchronous bilateral Wilms tumour in the SIOP WT 2001 Study: Report from the SIOP Renal Tumour Study Group (SIOP-RTSG)

Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

Wilms tumour

Rationale for the treatment of children with CCSK in the UMBRELLA SIOP–RTSG 2016 protocol

A tribute to Prof. Ondrej Hes, MD, PhD (1968–2022)

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