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A Role for Electrotonic Coupling in the Striatum in the Expression of Dopamine Receptor-mediated Stereotypies

Holly Moore
Anthony A Grace
Research30 May 2002
Neuropsychopharmacology

Volume: 27, P: 980-992
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

Volume: 31, P: 2722-2736
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Metformin treatment was found to be associated with acute increases in the appetite-suppressing metabolite Lac-Phe in several human observational and interventional studies.

Barry Scott
Emily A. Day
Lydia Lynch
ResearchOpen Access18 Mar 2024
Nature Metabolism

Volume: 6, P: 651-658

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