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Showing 1–3 of 3 results

Advanced filters: Author: Guangsong Su Clear advanced filters

Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity

Su et al. report that the super-enhancer K5aSE orchestrates Klf5andadditional targets via 3D chromatin interactions in ES cells, with CTCF-mediated chromatin domains maintaining this regulatory network essential for ES cell identity.

Guangsong Su
Bohan Chen
Wange Lu
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-21
Systematic decoding of functional enhancer connectomes and risk variants in human glioma

Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumour enhancers and uncover enhancer connectomes in glioma. In particular, they identify specific single-nucleotide polymorphisms associated with glioma risk and progression.

Jinfang Bi
Weipeng Mo
Wange Lu
ResearchOpen Access19 Aug 2025
Nature Cell Biology

P: 1-10
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide

Tengfei Shi
Dianhao Guo
Lei Zhang
ResearchOpen Access04 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-13