Nature Search

AR⁺TREM2⁺ macrophage induced pathogenic immunosuppression promotes prostate cancer progression

Androgen receptor (AR) usually drives prostate cancer cell growth, but its role in immune cells like macrophages, remains unclear. The authors here show that AR⁺TREM2⁺ macrophages exhibits enhanced immunosuppressive and tumour-promoting effects comping to its counterparts with the mechanism of upregulated APOE/TREM2/AR expression in inducing immunosuppressive gene profile in macrophage.

Qiaohua Wang
Yongjian Wu
Guanmin Jiang
ResearchOpen Access29 Jul 2025
Nature Communications

Volume: 16, P: 1-23
Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung

The efficacy of CAR-T cells is hindered by the immunosuppressive microenvironment of solid tumors. Here the authors report the design and characterization of anti-PD-L1-expressing inhalable nanovesicles loaded with the STING agonist cGAMP, showing enhanced CAR-T cell activity in both orthotopic lung cancer and lung metastasis models.

Tianchuan Zhu
Yuchen Xiao
Xi Huang
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Author Correction: Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

Yongjian Wu
Xiaomin Cheng
Xi Huang
Amendments and CorrectionsOpen Access15 Dec 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1
A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.

Sisi Kang
Mei Yang
Shoudeng Chen
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-11
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

Jieruo Gu, Jianjun Liu and colleagues report the results of a genome-wide association study of ankylosing spondylitis in Han Chinese. They identify two new susceptibility loci for this inflammatory disease and confirm strong associations with variants in the HLA-B region.

Zhiming Lin
Jin-Xin Bei
Jieruo Gu
Research04 Dec 2011
Nature Genetics

Volume: 44, P: 73-77
Association analysis of maize stem vascular bundle micro-characteristics with yield components based on micro-CT and identification of related genes

Yanru Wang
Ying Zhang
Chunjiang Zhao
ResearchOpen Access15 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

Yongjian Wu
Xiaomin Cheng
Xi Huang
ResearchOpen Access22 Jul 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-9
A novel ABA functional analogue B2 enhances drought tolerance in wheat

Yuyi Zhou
Rui He
Liusheng Duan
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15

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