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A deep generative model is developed for de novo molecular design and optimization by leveraging electron density. Wet-laboratory assays validated its reliability to generate diverse bioactive molecules—orthosteric and allosteric, inhibitors and activators.

This study presents a self-rectifying memristor (SRM) with high rectification ratio based on a TiN/HfO_x/Pt structure. It demonstrates minimal device-to-device and cycle-to-cycle variations, enabling scalability and suitability for in-memory computing. SRM-based crossbar arrays achieve software-comparable accuracy and show promise to enhance autonomous driving security and reliability.

Seawater is the most abundant source of uranium. This work shows a bipolar electrochemical mining process from seawater at ultra-low voltages, ensuring maximized extraction efficiency and minimized energy consumption.

Using a thermal Rb-Xe hybrid spin maser the authors report the observation of a time crystal. The formation of time crystal is caused by a strong retarded interaction and the new oscillation frequency scales with the delay time characterized by the phase lag of the original oscillations.

Developing Type I photosensitizers (PSs) is vital for tackling hypoxic intolerance of photodynamic therapy in the hypoxic microenvironment, but elusive due to the lack of a general molecular design strategy. Here the authors report a universal and simple method to covert traditional Type II PSs to Type I PSs.

Electrochemical capacitors are promising for miniaturized line filtering but suffer from sluggish ion migration. Here, the authors design a highly ion-conductive separator to replace the commercial ones, realizing a 120% capacitance improvement and line filtering at high-load power conditions.

Influenza virus uses metabotropic glutamate receptor 2 (mGluR2) as an endocytic receptor to enter cells through clathrin-mediated endocytosis.

Precise coupling of different or even contradictory material properties and biological characteristics is needed for tissue engineering but challenging. Here the authors report an all-in-one guided bone regeneration membrane that asymmetrically combines stiffness and flexibility, ingrowth barrier and ingrowth guiding, alongside anti-bacteria and cell-activation.

Early prediction of AKI-related clinical events and timely intervention for high-risk patients could improve outcomes. Here, the authors show a deep learning model that can identify patients with acute kidney injury (AKI) who are at high risk of death or dialysis at certain time points.

Conventional photodynamic therapy (PDT) is hindered by oxygen-dependent photosensitization pathways and high-power-density photoexcitation. Here, the authors develop polymer-based organic photosensitizers (PSs) through PS skeleton design and side-chain engineering to allow tumor-specific PDT under oxygen-free conditions using ultralow-power 808 nm photoexcitation.

Hydrogenation is an effective way to tune the property of metal oxides. Here, the authors report a simple approach to hydrogenate VO₂ in acid solution under ambient conditions by placing a small piece of low workfunction metal on VO₂ surface.

Miscanthus is widely used as a feedstock for cellulosic biofuel production. Genome sequencing shows that M. floridulus is most distantly related to other Miscanthus species and is more genetically diverse.

Synapses are surrounded by an extracellular matrix (ECM) of extremely long-lived proteins that is thought to only be remodeled by proteolysis and de novo synthesis. Here, the authors show an alternative molecular recycling mechanism that occurs for the key ECM protein Tenascin-R.

The authors reprogram chicken fibroblast cells to form primordial germ cells (PGCs) in one species (black feather Langshan chicken) and then show such PGCs can be transplanted and migrate into the genital ridge of another chicken species (White Plymouth Rock) to produce viable offspring with the Characteristics of donor.

Hydrological risks drive migration more than socioeconomic factors. Vulnerable groups often stay in high-risk areas or migrate nearby. The study reveals an S-shaped migration pattern influenced by settlement resilience and adaptability.

Water evaporation from the surface of cheap carbon-black materials can be used to generate sustained voltages of up to 1 V under ambient conditions.

A miniaturized narrow-channel in-plane electrochemical capacitor shows drastically reduced ionic resistances within both the electrode material and the electrolyte and an ultrahigh areal capacitance by downscaling the channel width with femtosecond-laser scribing.

The structure of the superconducting phase of iron-based superconductor K_xFe_2−ySe₂ is difficult to determine because it coexists with an predominant insulating phase. Ding et al. identify the superconducting filaments that provide clues to the structure of the parent phase of superconductivity.

H3K27me3 binding to the EED pocket of the Polycomb repressive complex 2 (PRC2) is required to activate PRC2. An allosteric small-molecule inhibitor of PRC2 was identified that binds to the EED pocket and blocks PRC2 methyltransferase activity in cells.

Infection is a major problem for dental implants with current antibacterial coatings losing efficacy quickly. Here, the authors report on the N-halamine polymeric coating of titanium implants to create a long-lasting renewable antibacterial layer and demonstrate application in vivo.

High frequency semen exposure has been associated with activation of anti-HIV mechanisms in HIV negative sex workers. Here, Abdulhaqq et al. show that repeated vaginal exposure to semen reduces vaginal infection by SIV in non-human primates, and is associated with lower CCR5 expression in CD4 T-cells and a local type-I interferon response.

The origins of the pair of X-ray bubbles, called eROSITA bubbles (eRBs), detected in the halo of Milky Way are debated. Here, the authors show hydrodynamical simulations suggesting circumgalactic medium wind model can explain asymmetric eRBs.

The high levels of water extraction from the Colorado, Murray, Orange and Yellow rivers are shown to be the main cause of reduced flows in these systems. Changes in governance are urgently required to preserve the health of these rivers, especially in light of the present and future impacts of climate change.

Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses expression of the methyltransferase EZH2, which limits production of antitumor effector molecules and enhances T cell apoptosis.

Some proteins move along DNA, searching for a specific target. Now these proteins are shown to follow a helical path, i.e., they rotate while sliding, hence maintaining a specific orientation to the DNA helix. This is accomplished by tracking single molecules of labeled human oxoguanine DNA glycosylase 1, alone or bound to a bulky streptavidin moiety, and calculating their diffusion constants.