Eremophilanes represent a prominent class of sesquiterpenoid natural products. Here, the authors report a series of eremophilane derivatives, including the aromatic structures of farfugin A and aza-janthinellin A, and the non-aromatic structure of phomenonol A, and show that the formation of farfugin A and aza-janthinellin A involves ring arrangement and aromatization process initiated by heteroatom nucleophilic addition and mediated by a FAD-dependent monooxygenase.
- Hengyi Xu
- Xianyan Zhang
- Guojian Zhang
