The key in engineering functional excitable tissues is to develop advanced conductive biomaterials that could guide cells to form electrically interconnected networks. This study aims to develop reduced graphene oxide functionalized silk nanofibrous biomaterials with controllable surface deposition. The composites exhibit uniform nanolayer of reduced graphene oxide, and well controlled conductivity and nanofibrous morphology. The scaffolds promote formation and functionalities of engineered cardiac tissues, and electrical stimulation further enhances these promotion effects. This research provides guidance for using reduced graphene oxide to fabricate conductive nanofibrous biomaterials for the regeneration of functional excitable tissues.
- Guoxu Zhao
- Huaibin Qing
- Xiaohui Zhang
