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Showing 1–2 of 2 results
Advanced filters: Author: Gwangsu Yoon Clear advanced filters
  • Oxidative damage to intracellular membrane proteins is critical to cells. Here, the authors use a water-oxidizing photocatalyst, generating ∙OH even under hypoxia, to show that membrane-specific protein oxidation triggers pyroptosis via non-canonical inflammasomes.

    • Chaiheon Lee
    • Mingyu Park
    • Tae-Hyuk Kwon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Conventional protein oxidation pathways typically involve free diffusion of reactive oxygen species (ROS), which primarily attack the protein surface. Here, the authors report a pathway of protein damage, O2-confined photooxidation, where O2 is captured in protein cavities and subsequently converted into multiple ROS which attack the protein interior.

    • Seoyoon Kim
    • Eojin Kim
    • Duyoung Min
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19