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Showing 1–50 of 92 results

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Resistance to viomycin conferred by RNA of either ribosomal subunit

T. YAMADA
Y. MIZUGICHI
H. G. WITTMANN
Research01 Oct 1978
Nature

Volume: 275, P: 460-461
Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction

An IgE antibody recognising Folate Receptor-alpha has been tested in clinical trials for ovarian cancer and preclinical studies show macrophage involvement in the anti-tumoural functions of IgE. Here the authors demonstrate that IgE induces proinflammatory activation of ovarian cancer patient macrophages, which reverses their immunosuppressive induction of Treg cells and promotes CD8⁺ T cell function.

Gabriel Osborn
Jacobo López-Abente
Sophia N. Karagiannis
ResearchOpen Access10 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Species Difference in the Biosynthesis of Vitamin C and Response to Diabetogenic Substances

M. C. NATH
C. H. CHAKRABORTY
KUSUM S. LAUL
Research23 Oct 1948
Nature

Volume: 162, P: 660-661
Testis weight, body weight and breeding system in primates

A. H. Harcourt
P. H. Harvey
R. V. Short
Research03 Sept 1981
Nature

Volume: 293, P: 55-57
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

The role of cortical PV neurons in the regulation of sleep architecture and homeostatic sleep rebound is not fully understood. Here, the authors show that CaMKII-mediated control of cortical parvalbumin-neuron activity regulates the homeostatic sleep rebound in mice.

Kazuhiro Kon
Koji L. Ode
Hiroki R. Ueda
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Sacrificial capillary pumps to engineer multiscalar biological forms

A patterning method using gallium-based engineered sacrificial capillary pumps for evacuation is described for generating structures in soft natural hydrogels across several length scales and enabling a wide range of tissue architectures to be fabricated.

Subramanian Sundaram
Joshua H. Lee
Christopher S. Chen
Research11 Dec 2024
Nature

Volume: 636, P: 361-367
Physical interaction between peroxisomes and chloroplasts elucidated by in situ laser analysis

Plant cell organelles interact dynamically, most notably during photosynthesis. A femtosecond laser technology, that creates localized micro-shockwaves, is used to precisely analyse adhesion forces between peroxisomes, mitochondria and chloroplasts.

Kazusato Oikawa
Shigeru Matsunaga
Mikio Nishimura
Research30 Mar 2015
Nature Plants

Volume: 1, P: 1-12
Thymic epithelium and the induction of transplantation tolerance in nude mice

R. K. Jordan
J. H. Robinson
A. L. Bentley
Research01 Apr 1985
Nature

Volume: 314, P: 454-456
Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

Pia Werner
Mark Voigt
Peter H. Seeburg
Research27 Jun 1991
Nature

Volume: 351, P: 742-744
Mammary Stimulation causes Prolactin Secretion in Non-lactating Women

ROBERT C. KOLODNY
LAURENCE S. JACOBS
WILLIAM H. DAUGHADAY
Research04 Aug 1972
Nature

Volume: 238, P: 284-286
LARGE DOSES OF DEXAMETHASONE FOR PREVENTION AND TRATMENT OF NARROW STRICTURES IN CAUSTIC DESOPHAGITIS

S Cadranel
P Rodesch
H R Hay
Research01 Jul 1986
Pediatric Research

Volume: 20, P: 700
Biologically diverse molecular variants within a single HIV-1 isolate

Amanda G. Fisher
Barbara Ensoli
Flossie Wong-Staal
Research01 Aug 1988
Nature

Volume: 334, P: 444-447
ISOLATION OF CAMPYLOBACTER PYLORIDIS IN CHRONIC GASTRITIS IN CHILDREN

S Cadranel
P Rodesch
Jp Butzler
Research01 Jul 1986
Pediatric Research

Volume: 20, P: 700
OESOPHAGEAL TRANSIT-TIME USING Bin-Kr IN CHILDREN WITH CAUSTIC OESOPHAGITIS

S Cadranel
P Rodesch
H Ham
Research01 Jul 1986
Pediatric Research

Volume: 20, P: 700
Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

IgE antibodies have shown anti-tumor activity, even superior to IgG, in preclinical models. However, all monoclonal antibodies in clinical use for cancer therapy are members of the IgG class. Here the authors report the results of a phase I clinical trial of a chimeric monoclonal IgE antibody, specific for the folate receptor-alpha, in patients with advanced solid cancer.

James Spicer
Bristi Basu
Sophia N. Karagiannis
ResearchOpen Access25 Jul 2023
Nature Communications

Volume: 14, P: 1-11
An anti-idiotype vaccine against experimental schistosomiasis

J. M. Grzych
M. Capron
A. Capron
Research04 Jul 1985
Nature

Volume: 316, P: 74-76
Zonation of supracrustal relics in the Archaean of Sierra Leone, Liberia, Guinea and Ivory Coast

H. R. ROLLINSON
Research01 Mar 1978
Nature

Volume: 272, P: 440-442
No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes

K Mitani
A Hangaishi
H Hirai
Research01 Jun 1997
Leukemia

Volume: 11, P: 863-865
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

IgE antibodies targeting cancer antigens can be used for immunotherapy. Here the authors present an IgE antibody targeting the melanoma-associated antigen, chondroitin sulphate proteoglycan 4, that recognises human melanoma, stimulates tumour cell cytotoxicity, and restricts tumour growth in humanised mouse models.

Jitesh Chauhan
Melanie Grandits
Heather J. Bax
ResearchOpen Access25 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Ontogenic Studies of Gastrointestinal Function. II. Lower Esophageal Sphincter Maturation in Neonatal Beagle Puppies

Steven B Spedale
Norman W Weisbrodt
Frank H Morriss JR.
Research01 Oct 1982
Pediatric Research

Volume: 16, P: 851-855
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

Intrinsic resistance to tyrosine kinase inhibitor (TKI) drugs is limiting the progress of targeted cancer therapies. The efficacy of TKIs relies on their inhibition of oncogenic signaling but also on the induction of apoptosis in cancer cells, driven by activation of pro-apoptotic BIM proteins. The authors identify a germline BIM polymorphism common in East Asian individuals that switches BIM splicing, eliminating the BH3 domain responsible for apoptosis induction. The polymorphism provides resistance to TKIs, such as BCR-ABL inhibitors in chronic myeloid leukemia and EGFR inhibitors in non–small-cell lung cancer samples, and drug sensitivity can be reinstated by addition of BH3-mimetic drugs. The polymorphism predicts treatment responses and outcome in East Asian patients with leukemia and lung cancer and could provide useful guidance for therapeutic implementation.

King Pan Ng
Axel M Hillmer
S Tiong Ong
Research18 Mar 2012
Nature Medicine

Volume: 18, P: 521-528
Small-RNA asymmetry is directly driven by mammalian Argonautes

Asymmetric selection of single-stranded guide RNAs from double-stranded RNA precursors is determined by Ago2, which detects 5′-nucleotide identity and thermodynamic stability of microRNA duplex ends via its MID domain.

Hiroshi I Suzuki
Akihiro Katsura
Kohei Miyazono
Research22 Jun 2015
Nature Structural & Molecular Biology

Volume: 22, P: 512-521
Fluorescence imaging of individual ions and molecules in pressurized noble gases for barium tagging in ¹³⁶Xe

Barium tagging is a key ingredient for future detectors of neutrinoless double beta decay in low-background environments. Here, the authors demonstrate fluorescence imaging of single Ba2+ ions in high pressure Xenon gas, by comparing activity between Ba2+ chelated and unchelated samples of crown-ether chemosensors.

N. K. Byrnes
E. Dey
A. Yubero-Navarro
ResearchOpen Access05 Dec 2024
Nature Communications

Volume: 15, P: 1-13
Using machine learning algorithms to enhance IoT system security

Hosam El-Sofany
Samir A. El-Seoud
Belgacem Bouallegue
ResearchOpen Access27 May 2024
Scientific Reports

Volume: 14, P: 1-19
Mr. R. Strachan

C. H.
Comments & Opinion10 May 1924
Nature

Volume: 113, P: 684-685
TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

The epigenetic mark 5-hmC alters gene expression and is known to be regulated by TET proteins. Here, the authors show that 5-hmC and TET2 are reduced in prostate cancer via androgen receptor-dependent miRNA expression and are inversely correlated with prognosis.

Ken-ichi Takayama
Aya Misawa
Satoshi Inoue
Research25 Sept 2015
Nature Communications

Volume: 6, P: 1-16
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

In a new study including 200 families who experienced perinatal death, adding genomic analyses to standard autopsies improved the identification of underlying pathogenic causes and informed genetic counseling.

Alicia B. Byrne
Peer Arts
Hamish S. Scott
ResearchOpen Access19 Jan 2023
Nature Medicine

Volume: 29, P: 180-189
Manometric Methods in Biology

H. B.
Books & Arts11 May 1935
Nature

Volume: 135, P: 774
A Printed Organic Amplification System for Wearable Potentiometric Electrochemical Sensors

Rei Shiwaku
Hiroyuki Matsui
Shizuo Tokito
ResearchOpen Access02 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
Ba⁺² ion trapping using organic submonolayer for ultra-low background neutrinoless double beta detector

One of the possible events signaling a neutrinoless double beta decay is a Xe atom decaying into a Ba ion and two electrons. Aiming at the realisation of a detector for such a process, the authors show that Ba ions can be efficiently trapped (chelated) in vacuum by an organic molecule layer on a surface.

P. Herrero-Gómez
J. P. Calupitan
J. T. White
ResearchOpen Access14 Dec 2022
Nature Communications

Volume: 13, P: 1-10
A Printed Organic Circuit System for Wearable Amperometric Electrochemical Sensors

Rei Shiwaku
Hiroyuki Matsui
Shizuo Tokito
ResearchOpen Access23 Apr 2018
Scientific Reports

Volume: 8, P: 1-8
Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers

Gabriel G. Malouf
Ronan Flippot
Abraham A. Hakimi
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Machine learning meta-analysis identifies individual characteristics moderating cognitive intervention efficacy for anxiety and depression symptoms

Thalia Richter
Reut Shani
Hadas Okon-Singer
ResearchOpen Access28 Jan 2025
npj Digital Medicine

Volume: 8, P: 1-15
351 THE EPIDEMIOLOGY OF HUMAN ROTAVIRUS INFECTION IN D.C. AREA THROUGH FOUR WINTERS

Carl D Brandt
Hyun W Kim
Robert H Parrott
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 422
A new representation of knowledge concerning human anatomy and function

By integrating concepts of computer graphics and artificial intelligence, novel ways of representing medical knowledge become possible. They allow unprecedented possibilities ranging from three-dimensional interactive atlases to systems for surgery rehearsal

K.H. Höhne
B. Pflesser
U. Tiede
Comments & Opinion01 Jun 1995
Nature Medicine

Volume: 1, P: 506-511
101 BIOFEEDBACK THERAPY FOR FECAL INCONTINENCE IN CHILDREN WITH MENINGOMYELOCELE

Arnold Wald
Richard H Michaels
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 456
Teleneurology and mobile technologies: the future of neurological care

Globally, access to neurological care remains limited for many people. However, technologies such as smart phones are now facilitating unprecedented access to remote care and specialist expertise. Here, Dorsey and colleagues discuss evidence of the benefits and risks of teleneurology for chronic disorders, including Parkinson disease, epilepsy and multiple sclerosis, as well as future trends and barriers to adoption.

E. Ray Dorsey
Alistair M. Glidden
Lee H. Schwamm
Reviews06 Apr 2018
Nature Reviews Neurology

Volume: 14, P: 285-297
BCR–ABL promotes neutrophil differentiation in the chronic phase of chronic myeloid leukemia by downregulating c-Jun expression

S Kobayashi
F Kimura
K Motoyoshi
Research09 Apr 2009
Leukemia

Volume: 23, P: 1622-1627
On the Science of Weighing and Measuring, and the Standards of Weight and Measure ^*

H. W. CHISHOLM
News04 Dec 1873
Nature

Volume: 9, P: 87-89
B cell lymphoma-associated hemophagocytic syndrome after PBSCT

T Takahashi
Y Kanda
Y Yazaki
Research24 Mar 1998
Bone Marrow Transplantation

Volume: 21, P: 623-625
PROXIMAL MUSCLE WEAKNESS RESPONDING TO SELENIUM THERAPY: A CASE REPORT

M R Brown
J M Lyons
H J Cohen
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 191
FAMILIAL HYPOKALAEMIA AND HYPOMAGNESAEMIA, GITELMAN'S SYNDROME, REPORT OF 6 CASES

D A Mccredie
H R Powell
E Rotenberg
Research01 Aug 1980
Pediatric Research

Volume: 14, P: 977
Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children

S. Takeoka
M. Unoki
M. Tamari
Research01 Feb 2001
Journal of Human Genetics

Volume: 46, P: 57-63
Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: a multifactorial analysis of TP53, p21, BAX and BCL-2

M Schuyer
M E L van der Burg
E M J J Berns
ResearchOpen Access30 Oct 2001
British Journal of Cancer

Volume: 85, P: 1359-1367
Activation of EVI1 transcripts with chromosomal translocation joining the TCRVβ locus and the EVI1 gene in human acute undifferentiated leukemia cell line (Kasumi-3) with a complex translocation of der(3)t(3;7;8)

K Suzukawa
T Kodera
K Morishita
Research09 Sept 1999
Leukemia

Volume: 13, P: 1359-1366
KAGRA: 2.5 generation interferometric gravitational wave detector

KAGRA is a new gravitational wave detector being built in Japan. Unlike LIGO/Virgo, it will operate at cryogenic temperatures with sapphire mirrors. KAGRA will help improve the localization of gravitational wave detections and determination of the source parameters.

T. Akutsu
M. Ando
Z.-H. Zhu
Reviews08 Jan 2019
Nature Astronomy

Volume: 3, P: 35-40
Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

M Iida
M Towatari
T Naoe
Research16 Apr 1999
Leukemia

Volume: 13, P: 585-589
Positional cloning of a Bombyx pink-eyed white egg locus reveals the major role of cardinal in ommochrome synthesis

M Osanai-Futahashi
K-i Tatematsu
H Sezutsu
Research02 Sept 2015
Heredity

Volume: 116, P: 135-145
RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia

Justine Decroocq
Rudy Birsen
Jerome Tamburini
ResearchOpen Access30 Mar 2022
Leukemia

Volume: 36, P: 1237-1252
Genetic alteration of the DCX gene in Japanese patients with subcortical laminar heterotopia or isolated lissencephaly sequence

M. Sakamoto
J. Ono
H. Kurahashi
Research01 May 2000
Journal of Human Genetics

Volume: 45, P: 167-170

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