Nature Search

A mechanosensitive transcriptional mechanism that controls angiogenesis

Rho signalling is shown to regulate angiogenesis in response to mechanical signals such as extracellular matrix elasticity, or the angiogenic factor VEGF. The pathway modulates the antagonistic functions of two transcription factors, TFII-I and GATA2, which regulate the expression of VEGFR2.

Akiko Mammoto
Kip M. Connor
Donald E. Ingber
Research26 Feb 2009
Nature

Volume: 457, P: 1103-1108
Two Remarkable Meteors

W. H. S. J. HOPE
Research17 May 1877
Nature

Volume: 16, P: 43
A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

Mitchell Dukovich
Yuji Wano
Warner C. Greene
Research11 Jun 1987
Nature

Volume: 327, P: 518-522
Cloud Colours

H. C.
Research17 May 1877
Nature

Volume: 16, P: 43-44
ACHealthChain blockchain framework for access control and privacy preservation in healthcare

Ahmed M. Tawfik
Ayman Al-Ahwal
Hala H. Zayed
ResearchOpen Access14 May 2025
Scientific Reports

Volume: 15, P: 1-25
Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy

The small GTPase ARF6 is known to regulate endocytosis and recycling of plasma membrane proteins. Here the authors show that tumourintrinsic ARF6 promotes an immunosuppressive microenvironment that accelerates melanoma progression but that is vulnerable to immune checkpoint blockade, mechanistically linked to ARF6-dependent recycling of interferon-gamma receptors in tumour cells.

Yinshen Wee
Junhua Wang
Allie H. Grossmann
ResearchOpen Access04 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function

A systemically administered peptide (CARSKNKDC) that homes to injured tissues, has inherent ability to promote wound healing. Here, the authors show that this peptide binds to syndecan-4 and activates ARF6 to trigger re-epithelialisation and the naturally occurring wound repair pathway.

Horacio Maldonado
Bryan D. Savage
Tero A. H. Järvinen
ResearchOpen Access06 Dec 2023
Nature Communications

Volume: 14, P: 1-23
Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes

Marilia O. Scliar
Hanaisa P. Sant’Anna
Eduardo Tarazona-Santos
Research26 Feb 2021
International Journal of Obesity

Volume: 45, P: 1017-1029
CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort study

Graziella D’ Agostino Ribeiro Naldi
Ariane Boccoli Minari
Suzane Kioko Ono
Research25 Feb 2025
The Pharmacogenomics Journal

Volume: 25, P: 1-9
787 ACCURATE DIAGNOSIS OF ACQUIRED OR CONGENITAL VIRAL INFECTIONS BY THE USE OF A SINGLE SERUM SAMPLE

Pauli O Leinikki
Isabel C Shekarchi
John L Sever
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 495
790 CEPHALEXIN IN CYSTIC FIBROSIS: A PLACEBO-CONTROLLED STUDY

Vera A Loening-Baucke
Elaine H Mischler
Martin G Myers
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 495
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

Toshimasa Yamauchi
Kohjiro Ueki
Takashi Kadowaki
Research06 Nov 1997
Nature

Volume: 390, P: 91-96
Inhibition of pp60^c-Src reduces Bcl-X_L expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

Rotem Karni
Richard Jove
Alexander Levitzki
Research18 Aug 1999
Oncogene

Volume: 18, P: 4654-4662
Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity

V Schirrmacher
O Josimovic-Alasevic
T Diamantstein
Research01 Jun 1987
British Journal of Cancer

Volume: 55, P: 583-587
Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease

K. Kyo
T. Muto
Y. Nakamura
Research01 Jan 2001
Journal of Human Genetics

Volume: 46, P: 5-20
Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells

M Semichon
H Merle-Béral
G Bismuth
Research01 Nov 1997
Leukemia

Volume: 11, P: 1921-1928
ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance

A Hashimoto
S Hashimoto
H Sabe
ResearchOpen Access12 Sept 2016
Oncogenesis

Volume: 5, P: e259
Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase

K Miura
Y Wakayama
N Mochizuki
ResearchOpen Access14 Jan 2013
Oncogene

Volume: 32, P: 5292-5301
TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118

J Oh
T Diaz
W G Stetler-Stevenson
Research20 Feb 2006
Oncogene

Volume: 25, P: 4230-4234
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial–mesenchymal transition

Y Komiya
Y Onodera
M Okada
ResearchOpen Access12 Sept 2016
Oncogenesis

Volume: 5, P: e258

Search

A mechanosensitive transcriptional mechanism that controls angiogenesis

Two Remarkable Meteors

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

Cloud Colours

ACHealthChain blockchain framework for access control and privacy preservation in healthcare

Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy

Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes

CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort study

787 ACCURATE DIAGNOSIS OF ACQUIRED OR CONGENITAL VIRAL INFECTIONS BY THE USE OF A SINGLE SERUM SAMPLE

790 CEPHALEXIN IN CYSTIC FIBROSIS: A PLACEBO-CONTROLLED STUDY

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

Inhibition of pp60^c-Src reduces Bcl-X_L expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity

Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease

Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase

TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118

The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial–mesenchymal transition

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