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Showing 51–100 of 114 results

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Strategies for delivering therapeutics across the blood–brain barrier

The blood–brain barrier is a perennial challenge for the delivery of therapeutics to the central nervous system. In their Review, Terstappen and colleagues discuss non-invasive approaches to brain delivery, particularly for biopharmaceuticals, some of which are now in clinical testing.

Georg C. Terstappen
Axel H. Meyer
Wandong Zhang
Reviews01 Mar 2021
Nature Reviews Drug Discovery

Volume: 20, P: 362-383
Origin of the cataclysmic Late Heavy Bombardment period of the terrestrial planets

R. Gomes
H. F. Levison
A. Morbidelli
Research26 May 2005
Nature

Volume: 435, P: 466-469
Bio-inspired, bioengineered and biomimetic drug delivery carriers

The exploitation of natural particulates, such as pathogens and mammalian cells, for drug delivery applications is a rapidly emerging field. Here, Yoo and colleagues discuss recent advances in the design of drug carriers based on natural particulates, provide an overview of their current development status and highlight the various applications and limitations of each approach.

Jin-Wook Yoo
Darrell J. Irvine
Samir Mitragotri
Reviews01 Jul 2011
Nature Reviews Drug Discovery

Volume: 10, P: 521-535
Focused shockwave induced blood-brain barrier opening and transfection

Yi Kung
Chiang Lan
Wen-Shiang Chen
ResearchOpen Access02 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
Agrocin 108 is a 5'-cytidine nucleotide bacteriocin containing a carbocyclic phosphoryl-ascorbate group

Christopher M. Elvin
Robert E. Asenstorfer
Max E. Tate
Research18 Jan 2018
The Journal of Antibiotics

Volume: 71, P: 438-446
Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

Ignacio Melero
Maria de Miguel Luken
Eugen Leo
Amendments and CorrectionsOpen Access25 Feb 2025
Nature

Volume: 639, P: E18
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel
F. Rodet
M. Salzet
ResearchOpen Access18 Jan 2016
Scientific Reports

Volume: 6, P: 1-13
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

Macrophages that populate the lymph nodes are known to clear viruses from the lymph and to initiate antiviral humoral immune responses. It is now shown that these macrophages also have another function: they prevent lymph-borne neurotropic viruses from entering the central nervous system. The mechanism is dependent on the production of type I interferon.

Matteo Iannacone
E. Ashley Moseman
Ulrich H. von Andrian
Research24 Jun 2010
Nature

Volume: 465, P: 1079-1083
(1) The Adolfo Stahl Lectures in Astronomy Delivered in San Francisco, California, in 1916–17 and 1917–18, under the Auspices of the Astronomical Society of the Pacific (2) Planetary Rotation Periods and Group Ratios

H. C. P.
Books & Arts11 Dec 1919
Nature

Volume: 104, P: 370-371
Scrapie a “gene”?

I.H. PATTISON
Correspondence16 Sept 1982
Nature

Volume: 299, P: 200
The Judgment of Paris, and some other Legends Astronomically Considered

H. R. HALL
Books & Arts21 Jan 1909
Nature

Volume: 79, P: 335
Gender-specific haplotype association of collagen α2 (XI) gene in ossification of the posterior longitudinal ligament of the spine

S. Maeda
H. Koga
I. Inoue
Research01 Jan 2001
Journal of Human Genetics

Volume: 46, P: 1-4
The two faces of titanium dioxide nanoparticles bio-camouflage in 3D bone spheroids

W. Souza
S. G. Piperni
A. R. Ribeiro
ResearchOpen Access27 Jun 2019
Scientific Reports

Volume: 9, P: 1-14
Identification of novel antistaphylococcal hit compounds

Galyna P. Volynets
Olga S. Iungin
Michael A. Tukalo
Research25 Jun 2024
The Journal of Antibiotics

Volume: 77, P: 665-678
Satellites to the fore

W. H. McCrea
News & Views01 Sept 1975
Nature

Volume: 257, P: 272
Chromatography

J. H. PURNELL
Books & Arts03 Nov 1972
Nature

Volume: 240, P: 58
Mechanisms of Disease: Helicobacter pylori-related gastric carcinogenesis—implications for chemoprevention

This Review considers the bacterial virulence factors and host inflammatory responses involved in the development of gastric cancer afterHelicobacter pylori infection, as well as the signaling pathways affected and possible molecular targets for intervention. The effect of H. pylori eradication and the modification of environmental conditions on the progression of the gastric carcinogenic process triggered by H. pyloriare also discussed.

Marco Romano
Vittorio Ricci
Raffaele Zarrilli
Reviews01 Nov 2006
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 3, P: 622-632
Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

G protein-coupled receptors (GPCRs) are key drug targets. In this article, Marshall and colleagues discuss the progress made towards generating GPCR-targeting antibodies, including which antigen formats and antibody platforms have been most successful. They review the current pipeline and outline outstanding challenges in antibody generation.

Catherine J. Hutchings
Markus Koglin
Fiona H. Marshall
Reviews14 Jul 2017
Nature Reviews Drug Discovery

Volume: 16, P: 787-810
Towards the sustainable discovery and development of new antibiotics

Antimicrobial resistance is an increasing threat to public health and encouraging the development of new antimicrobials is one of the most important ways to address the problem. This Roadmap article aims to bring together industrial, academic and political partners, and proposes both short-term and long-term solutions to this challenge.

Marcus Miethke
Marco Pieroni
Rolf Müller
Reviews19 Aug 2021
Nature Reviews Chemistry

Volume: 5, P: 726-749
Antitumor efficacy of oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes

A Kanzaki
H Kasuya
A Nakao
Research27 Jan 2012
Cancer Gene Therapy

Volume: 19, P: 292-298
Neisseria gonorrhoeae host adaptation and pathogenesis

The host-adapted human pathogenNeisseria gonorrhoeaeis the causative agent of gonorrhoea. In this Review, Quillin and Seifert provide an overview of the bacterial factors that are important for the different stages of pathogenesis, including transmission, colonization and immune evasion, and discuss the problem of antibiotic resistance.

Sarah Jane Quillin
H Steven Seifert
Reviews12 Feb 2018
Nature Reviews Microbiology

Volume: 16, P: 226-240
The language of the genes

N. H. Barton
J. S. Jones
News & Views02 Aug 1990
Nature

Volume: 346, P: 415-416
Particulate mediators of the bystander effect linked to suicide and interferon-β transgene expression in melanoma cells

Lucrecia Agnetti
Chiara Fondello
Liliana M. E. Finocchiaro
Research03 Mar 2020
Gene Therapy

Volume: 28, P: 38-55
Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis

Dávid Kovács
Nóra Igaz
Mónika Kiricsi
ResearchOpen Access13 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
The Business Side of a University

G. H. BRYAN
News30 Mar 1911
Nature

Volume: 86, P: 147-149
An American Contribution to Archæology ¹

H. R. HALL
News06 Sept 1906
Nature

Volume: 74, P: 468-470
Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase

U Haberkorn
ME Bellemann
G van Kaick
Research10 Jul 1998
Gene Therapy

Volume: 5, P: 880-887
Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

Edwin J. Vazquez-Cintron
Phillip H. Beske
Konstantin Ichtchenko
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-17
Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells

S Wang
M-f He
X-n Wang
ResearchOpen Access10 Oct 2013
Cell Death & Disease

Volume: 4, P: e856
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

A new wave of antivirals to fight hepatitis C infection has helped patients achieve a good quality of life, but drug resistance, side effects and a lack of pan-viral genotype coverage still remains a problem. This Review discusses current clinical studies and potential targets of the virus life cycle to tackle these issues and puts forward a paradigm to develop second-generation effective antivirals and drug combinations for achieving the ideal regimen of an all-oral, interferon-free therapeutic cocktail.

Troels K H Scheel
Charles M Rice
Reviews08 Jul 2013
Nature Medicine

Volume: 19, P: 837-849
Blocking Zika virus vertical transmission

Pinar Mesci
Angela Macia
Alysson R. Muotri
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
A ligand-based system for receptor-specific delivery of proteins

Mariano Maffei
Chiara Morelli
Paul A. Heppenstall
ResearchOpen Access16 Dec 2019
Scientific Reports

Volume: 9, P: 1-14
Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis

A Seckinger
T Meißner
D Hose
Research31 Aug 2009
Oncogene

Volume: 28, P: 3866-3879
Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes

Mayank Batra
Runxia Tian
Mehdi Mirsaeidi
ResearchOpen Access10 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

Aleksandra Bojarczuk
Katie A. Miller
Simon A. Johnston
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-15
Apoptotic cell clearance: basic biology and therapeutic potential

The removal of apoptotic cells by phagocytes is essential for the maintenance of tissue homeostasis and is usually immunologically silent. However, dysregulation of this process is associated with numerous inflammatory and autoimmune diseases, and thus the therapeutic manipulation of apoptotic cell clearance by phagocytes may be a means to treat these diseases.

Ivan K. H. Poon
Christopher D. Lucas
Kodi S. Ravichandran
Reviews31 Jan 2014
Nature Reviews Immunology

Volume: 14, P: 166-180
Positive muscle phenomena—diagnosis, pathogenesis and associated disorders

Positive muscle phenomena arise from spontaneous activity originating in motor neurons or in the muscle itself. Gea Drost and colleagues discuss the pathophysiology and the electromyographic and clinical features of this group of disorders. They also provide an algorithm to aid the differential diagnosis of these muscle phenomena.

Hans G. Kortman
Jan H. Veldink
Gea Drost
Reviews24 Jan 2012
Nature Reviews Neurology

Volume: 8, P: 97-107
M cell-depletion blocks oral prion disease pathogenesis

D S Donaldson
A Kobayashi
N A Mabbott
ResearchOpen Access01 Feb 2012
Mucosal Immunology

Volume: 5, P: 216-225
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence

The anatomy of secondary lymphoid organs defines the ability of an organism to respond to pathogens. In this Review, the authors describe how the functional microarchitecture of these structures is both a determinant and a result of antimicrobial immunity.

Tobias Junt
Elke Scandella
Burkhard Ludewig
Reviews01 Oct 2008
Nature Reviews Immunology

Volume: 8, P: 764-775
PET imaging of primary mediastinal tumours

K Kubota
S Yamada
T Ido
Research01 Apr 1996
British Journal of Cancer

Volume: 73, P: 882-886
Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo

W C Duivenvoorden
L K Beatty
J H Pinthus
ResearchOpen Access15 Jan 2013
British Journal of Cancer

Volume: 108, P: 327-333
Anti-GD2 immunoliposomes loaded with oxamate for neuroblastoma

William S. Panosyan
Daniel E. Panosyan
Eduard H. Panosyan
Research14 Feb 2023
Pediatric Research

Volume: 94, P: 458-461
Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach

J J P Gille
F B L Hogervorst
F H Menko
ResearchOpen Access07 Oct 2002
British Journal of Cancer

Volume: 87, P: 892-897
Stem cell-based therapy for human diseases

Duc M. Hoang
Phuong T. Pham
Liem Thanh Nguyen
ReviewsOpen Access06 Aug 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-41
Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

Anna-Lena Scherr
Andreas Mock
Bruno C. Köhler
ResearchOpen Access17 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-16
Peatland Acidobacteria with a dissimilatory sulfur metabolism

Bela Hausmann
Claus Pelikan
Alexander Loy
ResearchOpen Access23 Feb 2018
The ISME Journal

Volume: 12, P: 1729-1742
Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity

E J Ilett
R J Prestwich
A A Melcher
Research12 Mar 2009
Gene Therapy

Volume: 16, P: 689-699
Evaluation of T cells as carriers for systemic measles virotherapy in the presence of antiviral antibodies

H T Ong
K Hasegawa
K-W Peng
Research19 Oct 2006
Gene Therapy

Volume: 14, P: 324-333
Consequences of disruption of the interaction between p53 and the larger adenovirus early region 1B protein in adenovirus E1 transformed human cells

Fiona G Hutton
Andrew S Turnell
Roger JA Grand
Research21 Jan 2000
Oncogene

Volume: 19, P: 452-462
Detection of alphafetoprotein-expressing cells in the blood of patients with hepatoma and hepatitis

S-Y Jiang
R-Y Shyu
M-Y Yeh
Research01 Mar 1997
British Journal of Cancer

Volume: 75, P: 928-933

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