Nature Search

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

In Alzheimer’s disease (AD) tau and neurodegeneration have complex regional relationships. Here, the authors show neuronal hypometabolism discordant with tau burden defines functional resilience or susceptibility to Alzheimer’s pathology via limbic/cortical axes. Susceptible groups have faster cognitive decline and evidence of non-Alzheimer’s pathologies.

Michael Tran Duong
Sandhitsu R. Das
Ilya M. Nasrallah
ResearchOpen Access21 Mar 2022
Nature Communications

Volume: 13, P: 1-15
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
A touchless user interface based on a near-infrared-sensitive transparent optical imager

A transparent organic infrared photodetector array can be placed over a commercial display to provide a touchless control interface.

Takeshi Kamijo
Albert J. J. M. van Breemen
Gerwin H. Gelinck
ResearchOpen Access12 Jun 2023
Nature Electronics

Volume: 6, P: 451-461
Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

Brain-iron elevation is implicated in Alzheimer’s disease (AD), but the impact of the metal on disease outcomes has not been analysed in a longitudinal study. Here, the authors examine the association between the levels of ferritin, an iron storage protein, in the cerebrospinal fluid (CSF) of AD patients and show that CSF ferritin levels predict AD outcomes.

Scott Ayton
Noel G. Faux
Ansgar J. Furst
ResearchOpen Access19 May 2015
Nature Communications

Volume: 6, P: 1-9
Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

Herpesviruses contain two conserved fusion machinery components, gB and the gH–gL complex. The crystal structure of the gH ectodomain bound to gL from herpes simplex virus 2 forms an unusually tight complex that does not resemble any known fusogen. Instead, it is proposed that gH–gL may activate the fusogenic potential of gB by binding it directly.

Tirumala K Chowdary
Tina M Cairns
Ekaterina E Heldwein
Research04 Jul 2010
Nature Structural & Molecular Biology

Volume: 17, P: 882-888
Landau levels and magneto-transport property of monolayer phosphorene

X. Y. Zhou
R. Zhang
Kai Chang
ResearchOpen Access10 Jul 2015
Scientific Reports

Volume: 5, P: 1-12
583 NENATAL DIACNOSTIC RELATED GROUPS (DRC) PROSPECTIVE PAYMENT SYSTEM FOR TERTIARY NEONATAL INTENSIVE CARE CENTERS

Micheal B Resnick
Mario Ariet
John S Curran
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 208
585 ENTERIC ADENOVIRUS 40 & 41(EAds) IN GASTROENTERITIS S8S OF INFANTS & YOUNG CHILDREN

William J Rodriguez
Hyun W Kim
Robt H Parrott
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 208
587 NUTRITIONAL STATUS OF IMMIGRANT CHILDREN

L Schumacher
I G Pawson
N Kretchmer
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 208
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Urban pollution greatly enhances formation of natural aerosols over the Amazon rainforest

It remains unclear how urban emissions influence the formation of secondary organic aerosols (SOA), including in the Amazon forest. Here, the authors simulate the formation of SOAs in the Amazon using a high-resolution regional chemical transport model. They find that urban emissions of NOx from Manaus enhance the production of biogenic SOA by 60–200%.

Manish Shrivastava
Meinrat O. Andreae
Chun Zhao
ResearchOpen Access05 Mar 2019
Nature Communications

Volume: 10, P: 1-12
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer's disease is associated with tau spreading.

Nicolai Franzmeier
Julia Neitzel
Balebail Ashok Raj
ResearchOpen Access17 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca²⁺ channel–vesicle coupling

Coupling distances between synaptic vesicles and Ca²⁺ channels determine the efficacy of neurotransmission. Böhme et al. find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca²⁺ channels and synaptic vesicles.

Mathias A Böhme
Christina Beis
Stephan J Sigrist
Research15 Aug 2016
Nature Neuroscience

Volume: 19, P: 1311-1320
172 SEVERITY OF ILLNESS SCORING FOR PEDIATRIC INTENSIVE CARE UNIT PATIENTS

W H Craft
D C Grossman
D K Runyan
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 139
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

Julie Gonneaud
Alex T. Baria
Etienne Vachon-Presseau
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-17
43 HULTIVARIATE ANALYSIS OF FACTORS RELATED TO NON-HEROLYTIC HYPERBI-LIRUBINEMIA OF FULL-TERM NEWBORN INFANTS

C Corchia
H C Sanna
K Opzalesi
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 268
A Dataset Showing a Century of Evolution in the Complexity of the United States Legal Code

Dawoon Jeong
James Holehouse
Hyejin Youn
ResearchOpen Access06 Jan 2026
Scientific Data

Volume: 13, P: 1-19
Plasma apolipoprotein A-I is a causal protective factor in sepsis

Kyle R. Campbell
Kantimas Sitthikool
Keith R. Walley
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
Regional Cerebral Blood Flow after Hemorrhagic Hypotension in the Preterm, Near-Term, and Newborn Lamb

W Szymonowicz
A M Walker
L Cussen
Research01 Oct 1990
Pediatric Research

Volume: 28, P: 361-366
Monosynaptic inputs to new neurons in the dentate gyrus

Adult neurogenesis in the mammalian brain is implicated in the storage and processing of memories. Vivaret al.label afferents to new dentate gyrus granule cells and find that they receive direct input from the perirhinal and lateral entorhinal cortex and that these inputs enable spatial pattern separation.

Carmen Vivar
Michelle C. Potter
Henriette van Praag
Research02 Oct 2012
Nature Communications

Volume: 3, P: 1-11
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

Marcos H. Hatada
Xiaode Lu
Jennifer L. Karas
Amendments and Corrections12 Apr 2007
Nature

Volume: 446, P: 824
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
A conserved proline switch on the ribosome facilitates the recruitment and binding of trGTPases

Recruitment of elongation factor EF-G to the ribosome requires interaction between ribosomal proteins L12 and L11. New analyses identify a proline switch in L11, with the cis configuration allowing direct interaction between L11 and L12. EF-G has peptidyl-prolyl cis-trans isomerase activity driving the cis-trans isomerization of the proline switch, which might be a universal mechanism for efficient turnover of translational GTPases.

Li Wang
Fang Yang
Yan Qin
Research11 Mar 2012
Nature Structural & Molecular Biology

Volume: 19, P: 403-410
CD3 directed bispecific antibodies induce increased lymphocyte–endothelial cell interactions in vitro

G Molema
J W Cohen Tervaert
L F M H de Leij
ResearchOpen Access17 Dec 1999
British Journal of Cancer

Volume: 82, P: 472-479
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

Leonard van den Berg, Roel Ophoff and colleagues present a genome-wide association study of sporadic amyotrophic lateral sclerosis. The work uncovers associated SNPs at 9p21.2 and an associated locus at 19p13.3 mapping to the UNC13A gene.

Michael A van Es
Jan H Veldink
Leonard H van den Berg
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1083-1087
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.

Eric M. Reiman
Joseph F. Arboleda-Velasquez
Yi Zhao
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-11
BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion

A Jin
T Kurosu
O Miura
Research06 Mar 2006
Oncogene

Volume: 25, P: 4332-4340
Phase-field modeling of colloid-polymer mixtures in microgravity

Lauren Barnes
Boris Khusid
Anand U. Oza
ResearchOpen Access01 Sept 2025
npj Microgravity

Volume: 11, P: 1-14
Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Late-onset Alzheimer's disease (LOAD) is a complex multi-factorial disorder. Here, the authors perform a data-driven analysis of LOAD progression, including multimodal brain imaging, plasma and CSF biomarkers, and find vascular dysfunction is among the earliest and strongest altered events.

Y. Iturria-Medina
R. C. Sotero
Ansgar J. Furst
ResearchOpen Access21 Jun 2016
Nature Communications

Volume: 7, P: 1-14
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.

Julia Neitzel
Nicolai Franzmeier
Michael Ewers
ResearchOpen Access22 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Quantification and characterisation of commensal wild birds and their interactions with domestic ducks on a free-range farm in southwest France

Chloé Le Gall-Ladevèze
Claire Guinat
Guillaume Le Loc’h
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-13
“Anomalous” Water

D. H. EVERETT
J. M. HAYNES
P. J. MCELROY
Correspondence25 Oct 1969
Nature

Volume: 224, P: 394
Probing CP symmetry and weak phases with entangled double-strange baryons

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

M. Ablikim
M. N. Achasov
J. H. Zou
ResearchOpen Access01 Jun 2022
Nature

Volume: 606, P: 64-69
Seasonality and reduced nitric oxide titration dominated ozone increase during COVID-19 lockdown in eastern China

Hongli Wang
Cheng Huang
Hang Su
ResearchOpen Access28 Mar 2022
npj Climate and Atmospheric Science

Volume: 5, P: 1-7
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The BIN1 SNP rs744373 is associated with higher CSF tau and phosphorylated tau levels. Here the authors show, using PET imaging, that this SNP is associated with tau accumulation in the brain as well as impaired memory in older individuals without dementia.

Nicolai Franzmeier
Anna Rubinski
Ansgar J. Furst
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.

Taylor W. Schmitz
R. Nathan Spreng
Ansgar J. Furst
ResearchOpen Access04 Nov 2016
Nature Communications

Volume: 7, P: 1-13
RETICULOENDOTHELIAL CLEARANCE OF TYPE III GROUP B STREPTOCOCCI OPSONIZED WITH TYPE III SPECIFIC MONOCLONAL ANTIBODIES OF IgM OR IgG2a ISOTYPES IN AN EXPERIMENTAL RAT MODEL

Ann O Shigeoka
James M Bathras
Harry R Hill
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 334
CALCEMIC RESPONSES TO PHOTIC AND PHARMACOLOGIC MANIPULATION OF SERUM MELATONIN

D O Hakanson
R Penny
W H Bergstrom
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 168
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-15
Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population

Gyorgy Petrovics
Douglas K. Price
Michael Dean
ResearchOpen Access12 Dec 2018
Prostate Cancer and Prostatic Diseases

Volume: 22, P: 406-410
Dynamic Cerebral Autoregulation in Sick Newborn Infants

Geraldine B Boylan
Kevin Young
David H Evans
Research01 Jul 2000
Pediatric Research

Volume: 48, P: 12-17
100 EVALUATION OF PATIENTS WITH THALASSEMIA BY ECHOCARDIOGRAPHY

Kathryn H Ehlers
Aaron R Levin
Mary Allen Engle
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 380
97 DIGOXIN TOXICITY ASSOCIATED WITH LOW DOSAGE MAINTENANCE THERAPY IN PREMATURE INFANTS

Nirmala S Desai
Thomas H Pauly
John F Keane
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 380
99 MYOCARDIAL NECROSIS IN STRESSED NEWBORNS

William H Donnelly
Richard L Bucciarelli
Donald V Eitzman
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 380
A NEW VARIANT OF GLUCOSEPHOSPHATE ISOMERASE (GPI) DEFICIENCY WITH CONGENITAL HEMOLYTIC ANEMIA

Hans H Koch
Werner Schroter
Research01 Feb 1974
Pediatric Research

Volume: 8, P: 141
171 MACROPHAGE INFILTRATION AND MATRIX DISRUPTION IN∼RDS

Simon H Murch
Thomas T Macdonald
Kate L Costeloe
Research01 Jul 1994
Pediatric Research

Volume: 36, P: 31
Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells

T Terakawa
H Miyake
M Fujisawa
ResearchOpen Access20 Oct 2009
British Journal of Cancer

Volume: 101, P: 1731-1739
The sequence and analysis of duplication-rich human chromosome 16

Joel Martin
Cliff Han
Len A. Pennacchio
Research23 Dec 2004
Nature

Volume: 432, P: 988-994

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