The mechanisms for disease progression in alcohol-related steatohepatitis are incompletely understood. Here the authors report that binge drinking on top of chronic alcohol consumption in mice triggers the release of glutamate by hepatocytes, leading to liver inflammation via mGluR5/NOX2 -mediated reactive oxygen species production in Kupffer cells.
- Keungmo Yang
- Kyurae Kim
- Won-Il Jeong
