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Fine particulate matter has been linked to acute coronary syndrome, but the key constituents remain unclear. Here, the authors show that organic matter and black carbon have the largest effects on acute coronary syndrome onset, and contributed most to the joint impacts.

Hf_0.5Zr_0.5O₂ ferroelectric capacitors undergo a continuous transition from a positive effective to a fully inverted negative piezoelectric coefficient d₃₃ upon electrical cycling. With proper ac training, both the net effective and the local piezoresponses can be nullified while the polarization is kept fully switchable.

Clinically identified mutations in CTCF have been linked to adverse developmental outcomes. Here, the authors explore the regulatory roles of the CTCF^R567W point mutation, by introducing it into both murine models and human embryonic stem cell-derived cortical organoid models.

Coinage-metal-based cyclic trinuclear complexes have potential in diverse applications, but their use in biochemical applications has been limited due to particle size and hydrophobicity. Here, the authors report the development of such complexes with multi-photon luminescent properties for use in cell imaging.

Flood exposure can increase the risk of intimate partner violence. Intra-household and societal gender inequalities can further exacerbate this vulnerability.

Hu et al. report switchable ferroelectricity and photoelectric robustness in organic-inorganic hybrid perovskite from bulk single crystal and scaling down to monolayer. Nanoscale Hecht equation is developed to estimate photoelectric robustness for nanoflakes.

Flooding impacts billions globally and indirect health effects are not sufficiently examined, especially for women in developing countries. Here, the authors show that flood exposure during pregnancy correlates with a higher risk of pregnancy loss, particularly for marginalized women, revealing increased health disparities in a changing climate.

Floods are becoming more frequent and severe, with major impacts on human health. Here, authors show increased risks of infant mortality associated with flood exposure, and the risks remain elevated for up to four years after the flood event.

The authors analyse data from 272 Chinese cities, projecting that compound heatwaves will cause higher burdens for all major cardiopulmonary diseases than daytime or nighttime heatwaves, especially under scenarios with higher emissions and ageing and in areas with high summer temperature variability.

The retinal foveola in the primate eye is critical for seeing fine details, color, text and faces. Using ultrahigh-field functional magnetic resonance imaging, Qian et al discover that there is a highly specialized cortical brain region for processing foveolar information.

Immunotherapy with immune checkpoint inhibitors and targeted therapy with BRAF and MEK inhibition have revolutionized the treatment of melanoma. Here the authors report the results of a phase II trial of neoadjuvant cobimetinib (MEK inhibitor) and atezolizumab (anti-PD-L1) with or without the BRAF inhibitor vemurafenib in patients with resectable Stage III melanoma.

Extreme rainfall events, amplified by climate change, can stress public health, but efforts to assess health impacts have been fragmented so far. A study now analyses the relation between extreme rainfall and mortality from respiratory diseases across urban environments in East Asia.

Metabolic conditions associated with alterations of the gut microbiome, such as obesity and diabetes, predispose to gallstone disease. Here the authors demonstrate that the gut microbiome, in particular the genus Desulfovibrionale, contribute to gallstone formation in mice.

Cortical visual area V4 contains cells with diverse response properties, including preference for color, orientation, disparity and higher order features. Tanigawa et al. used intrinsic optical imaging to reveal that regions with preferential response to color or luminance are largely separate from orientation-selective regions.

A community-led randomized controlled trial in China showed that a pay-it-forward incentives increased the uptake of hepatitis B and C virus testing in men who have sex with men as compared with standard-of-care.

HfO₂ is a promising ferroelectric material for applications in electronics but knowledge on its ferroic and electromechanical response properties is still lacking. Here, the authors demonstrate the peculiar piezoresponse of HfO₂, predicting on how to reverse its sign by means of a biaxial strain.

The striped polarization domains in a BiFeO₃/TbScO₃ heterostructure induce alternating p- and n-type doping at the interface, giving rise to strongly anisotropic in-plane conductance.

As the leading cause of vision loss in working-age adults, diabetic retinopathy requires routinely retinal screening. Here the authors develop a deep learning system that can facilitate the screening by providing real-time image quality assessment, lesions detection, and grades across the disease spectrum.

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Voltage control of magnetization is critical for the development of antiferromagnetic spintronics. Here, using magnetic force microscopy and Hall measurements, Mahmood et al. demonstrate controlled rotation of the Néel vector in a heterostructure composed of Pt and antiferromagnetic B:Cr₂O₃.

The honeycomb lattice with a spin-orbit interaction can give rise to exotic quantum states. With the measurements of bulk properties and inelastic neutron scattering, Lin et al demonstrate the existence of a field induced spin-disordered state in Na₂Co₂TeO₆ and extend the Kitaev model to 3d system.

Controlling the polarization state in ferroeletric materials is a prerequisite for their application. Here an approach is presented to optically manipulate the polarization of ferroelectric BaTiO₃ by exploiting photogenerated carriers at the interface with a two-dimensional semiconducting MoS₂ film.

The existing hole-transporting materials cause problems in the cost and scalability of the perovskite solar cells. Here Wu et al. fabricate high efficiency cells by molecularly doping the perovskite layer without using hole-transporting layers, thus simplify the device architecture and processing steps.

The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.

Combining immune checkpoint inhibition with radiotherapy–radiodynamic therapy, enabled by intratumorally injected nanoscale metal–organic frameworks, promotes systemic antitumour immunity and tumour rejection in mouse models of breast and colorectal cancer.

Melanoma cells release programmed death-ligand 1 (PD-L1) on the surface of circulating exosomes, suggesting a mechanism by which tumours could evade the immunesystem, and the potential application of exosomal PD-L1 to monitor patient responses to checkpoint therapies.

The receptor LILRB4 on monocytic leukaemia cells suppresses T cell activity and support the infiltration of tumour cells into tissues.

The transboundary health impacts of air pollution associated with the international trade of goods and services are greater than those associated with long-distance atmospheric pollutant transport.