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Metabolism archetype cancer cells induce protumor TREM2⁺ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma

Tumour cells can alter the function and metabolism of immune cells to reduce anti-tumour responses. Here the authors use single cell sequencing of HCC and show three tumour archetypes; metabolism, inflammation and stemness and the metabolism archetype are found in association with TREM⁺ macrophages which restrict immune cell infiltration into the tumour microenvironment.

Tianhao Chu
Guiqi Zhu
Yinghong Shi
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-25
Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms

Sheila F. Lumley
Chris Kent
Philippa C. Matthews
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
Comparison of recombinant and urinary follicle-stimulating hormones over 2000 gonadotropin-releasing hormone antagonist cycles: a retrospective study

Wei Pan
Haiting Tu
ShuJie Liao
ResearchOpen Access29 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Seasonal catchment memory of high mountain rivers in the Tibetan Plateau

This study investigates the seasonal catchment memory of rivers in the Tibetan Plateau, with the help of a water storage change model. Understanding catchment memory can aid in hydrological forecasts and water resource management

Haiting Gu
Yue-Ping Xu
Yuxue Guo
ResearchOpen Access01 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Engineered PD-L1 co-expression in PD-1 knockout and MAGE-C2-targeting TCR-T cells augments the cytotoxic efficacy toward target cancer cells

Fangxin Zhao
Xuan Zhang
Jianqiang Wu
ResearchOpen Access07 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury

Ranran Li
Mei Meng
Lei Li
ResearchOpen Access06 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-14

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Metabolism archetype cancer cells induce protumor TREM2+ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma

Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms

Comparison of recombinant and urinary follicle-stimulating hormones over 2000 gonadotropin-releasing hormone antagonist cycles: a retrospective study

Seasonal catchment memory of high mountain rivers in the Tibetan Plateau

Engineered PD-L1 co-expression in PD-1 knockout and MAGE-C2-targeting TCR-T cells augments the cytotoxic efficacy toward target cancer cells

ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury

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Metabolism archetype cancer cells induce protumor TREM2⁺ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma