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Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells

Human hematopoietic cells derived from pluripotent cells repopulate multiple blood lineages in mice.

Elizabeth S. Ng
Gulcan Sarila
Andrew G. Elefanty
ResearchOpen Access02 Sept 2024
Nature Biotechnology

Volume: 43, P: 1274-1287
Medial HOXA genes demarcate haematopoietic stem cell fate during human development

Mikkola and colleagues show that medial HOXA gene expression, induced by retinoic acid signalling, marks the establishment of the definitive HSC fate and controls HSC identity and function.

Diana R. Dou
Vincenzo Calvanese
Hanna K. A. Mikkola
Research16 May 2016
Nature Cell Biology

Volume: 18, P: 595-606
MYCT1 controls environmental sensing in human haematopoietic stem cells

MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.

Júlia Aguadé-Gorgorió
Yasaman Jami-Alahmadi
Hanna K. A. Mikkola
ResearchOpen Access05 Jun 2024
Nature

Volume: 630, P: 412-420
MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

MLLT3 is identified as a crucial regulator of the self-renewal of human haematopoietic stem cells, and helps to maintain an active chromatin state in haematopoietic stem-cell regulatory genes during culture.

Vincenzo Calvanese
Andrew T. Nguyen
Hanna K. A. Mikkola
Research27 Nov 2019
Nature

Volume: 576, P: 281-286
Targeting leukemia stem cells

Acute myeloid leukemia stem cells can be made susceptible to chemotherapy by inducing them to divide.

Hanna K A Mikkola
Caius G Radu
Owen N Witte
News & Views01 Mar 2010
Nature Biotechnology

Volume: 28, P: 237-238
DNA methylation is a guardian of stem cell self-renewal and multipotency

Epigenetic marks, such as DNA methylation and histone modifications, undergo dynamic changes during cellular differentiation and development. A new study demonstrates that DNA methylation by Dnmt1 protects essential stem cell properties in both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) by silencing differentiation programs that interfere with self-renewal and multipotency.

Laurraine-Marcelle Gereige
Hanna K A Mikkola
News & Views01 Nov 2009
Nature Genetics

Volume: 41, P: 1164-1166
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

Hanna K. A. Mikkola
Jenny Klintman
Stuart H. Orkin
Research19 Jan 2003
Nature

Volume: 421, P: 547-551
Mapping human haematopoietic stem cells from haemogenic endothelium to birth

The HSC signature RUNX1⁺HOXA9⁺MLLT3⁺MECOM⁺HLF⁺SPINK2⁺ distinguishes haematopoietic stem cells from their endothelial precursors and differentiated progenitors throughout ontogeny

Vincenzo Calvanese
Sandra Capellera-Garcia
Hanna K. A. Mikkola
Research13 Apr 2022
Nature

Volume: 604, P: 534-540
Haemogenic endocardium contributes to transient definitive haematopoiesis

Cardiac and endocardial/endothelial cells arise from progenitor cells expressing multiple haematopoietic transcription factors. Nakano and colleagues find that Nkx2–5-positive endocardial cells serve as a de novosource for definitive haematopoietic progenitors during mammalian embryogenesis.

Haruko Nakano
Xiaoqian Liu
Atsushi Nakano
Research05 Mar 2013
Nature Communications

Volume: 4, P: 1-10
MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.

Wenyuan Wang
Tonis Org
Hanna K. A. Mikkola
ResearchOpen Access10 Aug 2016
Nature Communications

Volume: 7, P: 1-15
Differentiation of human embryonic stem cells to HOXA⁺ hemogenic vasculature that resembles the aorta-gonad-mesonephros

Human embryonic stem cells are differentiated to cells similar to the embryonic aorta-gonad-mesonephros, which gives rise to hematopoietic stem cells.

Elizabeth S Ng
Lisa Azzola
Andrew G Elefanty
Research17 Oct 2016
Nature Biotechnology

Volume: 34, P: 1168-1179
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

'Lymphoid priming' in human bone marrow is traditionally thought to begin with the expression of CD10 on CD34⁺ progenitors. Crooks and colleagues now demonstrate lymphoid priming in a subset of CD10^–CD34⁺ progenitors that are CD62L^hi.

Lisa A Kohn
Qian-Lin Hao
Gay M Crooks
Research02 Sept 2012
Nature Immunology

Volume: 13, P: 963-971
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury

During cardiac tissue formation it is unclear whether newly generated myocytes originate from cardiac progenitor cells or from pre-existing cardiomyocytes. Here, the authors use a stochastic four-colour reporter system (Rainbow) to identify the source of new cardiomyocytes during mouse development.

Konstantina-Ioanna Sereti
Ngoc B. Nguyen
Reza Ardehali
ResearchOpen Access21 Feb 2018
Nature Communications

Volume: 9, P: 1-13
Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes

Human development provides a roadmap for advancing pluripotent stem cell-based regenerative therapies. Here the authors mapped human skeletogenesis using RNA sequencing on 5 cell types from a single foetal stage as well as chondrocytes at 4 stages in vivo and 2 stages during in vitro differentiation.

Gabriel B. Ferguson
Ben Van Handel
Denis Evseenko
ResearchOpen Access07 Sept 2018
Nature Communications

Volume: 9, P: 1-16
Transcriptional Activators, Repressors, and Epigenetic Modifiers Controlling Hematopoietic Stem Cell Development

Michael A Teitell
Hanna K A Mikkola
Reviews01 Apr 2006
Pediatric Research

Volume: 59, P: 33-39

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Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells

Medial HOXA genes demarcate haematopoietic stem cell fate during human development

MYCT1 controls environmental sensing in human haematopoietic stem cells

MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment

Targeting leukemia stem cells

DNA methylation is a guardian of stem cell self-renewal and multipotency

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

Mapping human haematopoietic stem cells from haemogenic endothelium to birth

Haemogenic endocardium contributes to transient definitive haematopoiesis

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

Differentiation of human embryonic stem cells to HOXA⁺ hemogenic vasculature that resembles the aorta-gonad-mesonephros

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

Analysis of cardiomyocyte clonal expansion during mouse heart development and injury

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes

Transcriptional Activators, Repressors, and Epigenetic Modifiers Controlling Hematopoietic Stem Cell Development

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