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Showing 1–6 of 6 results

Advanced filters: Author: Hans-Georg Sprenger Clear advanced filters

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

Sumeet A. Khetarpal
Haobo Li
Anthony Rosenzweig
Research24 Sept 2025
Nature Cardiovascular Research

P: 1-18
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Sprenger et al. find that cytosolic pyrimidine levels regulate the release of mitochondrial DNA and activation of cGAS–STING.

Hans-Georg Sprenger
Thomas MacVicar
Thomas Langer
ResearchOpen Access26 Apr 2021
Nature Metabolism

Volume: 3, P: 636-650
Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo

Leslie M. Stevens
Hans Georg Frohnhöfer
Christiane Nüsslein-Volhard
Research16 Aug 1990
Nature

Volume: 346, P: 660-663
Lactate regulates cell cycle by remodelling the anaphase promoting complex

Discovery of a biochemical mechanism through which lactate binds and inhibits the SUMO protease SENP1, stimulating timed degradation of cell cycle proteins, and resulting in mitotic exit.

Weihai Liu
Yun Wang
Edward T. Chouchani
Research15 Mar 2023
Nature

Volume: 616, P: 790-797
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

Under conditions such as hypoxia or starvation, an mTORC1-lipid signalling pathway initiates mitochondrial proteolysis by YME1L.

Thomas MacVicar
Yohsuke Ohba
Thomas Langer
Research06 Nov 2019
Nature

Volume: 575, P: 361-365
m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration

Maria Patron
Hans-Georg Sprenger
Thomas Langer
ReviewsOpen Access16 Feb 2018
Cell Research

Volume: 28, P: 296-306