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The thrombin receptor PAR1 orchestrates changes in lymphatic endothelial cell junction morphology to augment lymphatic drainage during lung injury

Chou et al. demonstrate that activation of the thrombin receptor protease-activated receptor 1 in the lung lymphatic vasculature mediates morphological changes in lymphatic endothelial cell junctions to augment lung lymphatic drainage in models of lung injury.

Chou Chou
Camila Ceballos Paredes
Hasina Outtz Reed
ResearchOpen Access17 Jul 2025
Nature Cardiovascular Research

Volume: 4, P: 964-975
Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

Notch signaling is known to modulate macrophage polarization. Hu and colleagues show that the Notch–RBP-J axis controls the expression of M1 macrophage–specific genes by promoting translation of the transcription factor IRF8.

Haixia Xu
Jimmy Zhu
Xiaoyu Hu
Research20 May 2012
Nature Immunology

Volume: 13, P: 642-650
Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice

Barbara D. Summers
Kihwan Kim
Hasina Outtz Reed
ResearchOpen Access23 Mar 2022
Scientific Reports

Volume: 12, P: 1-14

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