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Showing 1–20 of 20 results
Advanced filters: Author: Heather Christofk Clear advanced filters

  • Over the past decade, the field of metabolism has witnessed remarkable scientific discoveries that reshaped the understanding of metabolic physiology and disease. As we launch Nature Metabolism, we look at what the future holds for metabolic research.

    • Fredrik Bäckhed
    • Elisabetta Bugianesi
    • Matthias Tschöp
    Comments & Opinion
    Nature Metabolism
    Volume: 1, P: 2-4

  • The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate viral replication, and that inhibition of mTORC1, a master metabolic regulator, suppresses viral replication.

    • Peter J. Mullen
    • Gustavo Garcia Jr
    • Heather R. Christofk
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.

    • Abigail S. Krall
    • Heather R. Christofk
    News & Views
    Nature
    Volume: 496, P: 38-40

  • Many tumour cells express the M2 form of pyruvate kinase rather than the usual M1 form. PKM2 is now shown to promote tumorigenesis and switch the cellular metabolism to increased lactate production and reduced oxygen consumption, recapitulating key aspects of the Warburg effect.

    • Heather R. Christofk
    • Matthew G. Vander Heiden
    • Lewis C. Cantley
    Research
    Nature
    Volume: 452, P: 230-233

  • Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.

    • Abigail S. Krall
    • Shili Xu
    • Heather R. Christofk
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.

    • Abigail S. Krall
    • Heather R. Christofk
    News & Views
    Nature Cell Biology
    Volume: 17, P: 1515-1517

  • A positron emission tomography imaging tracer is developed to image mitochondrial function in vivo, and application of this tracer to a mouse model of lung cancer identifies distinct functional mitochondrial heterogeneity between tumour cells.

    • Milica Momcilovic
    • Anthony Jones
    • David B. Shackelford
    Research
    Nature
    Volume: 575, P: 380-384

  • Viruses can reprogram glutamine metabolism of host cells to support bioenergetics demands of viral replication. Here the authors show that adenoviral infection leads to enhanced glutamine metabolism through virus-mediated activation of MYC, which is required for optimal progeny virion generation.

    • Minh Thai
    • Shivani K. Thaker
    • Heather R. Christofk
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • A mechanism whereby the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2) can be regulated by tyrosine kinase signalling pathways through an ability to bind tyrosine-phosphorylated proteins is revealed.

    • Heather R. Christofk
    • Matthew G. Vander Heiden
    • Lewis C. Cantley
    Research
    Nature
    Volume: 452, P: 181-186

  • A small-molecule activator specific for PKM2 binds to a site distinct from the endogenous activator fructose-1,6-bisphosphate, promoting tetramerization and constitutive activation of PKM2, to inhibit xenograft tumor growth in mice.

    • Dimitrios Anastasiou
    • Yimin Yu
    • Matthew G Vander Heiden
    Research
    Nature Chemical Biology
    Volume: 8, P: 839-847

  • Cell division requires the action of key regulator proteins called cyclins and CDKs. It emerges that a cyclin–CDK complex can regulate cell metabolism, and targeting this metabolic regulation causes tumour regression in mice. See Letter p.426

    • Abigail S. Krall
    • Heather R. Christofk
    News & Views
    Nature
    Volume: 546, P: 357-358

  • Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.

    • Aimee Flores
    • John Schell
    • William E. Lowry
    Research
    Nature Cell Biology
    Volume: 19, P: 1017-1026

  • Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutarate—and target of rapamycin (TOR).

    • Randall M. Chin
    • Xudong Fu
    • Jing Huang
    Research
    Nature
    Volume: 510, P: 397-401